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Multicontrats MRI Improved the Clinico-Radiological Correlation in Early Multiple Sclerosis Patients with Minor Deficits

Publications associées (40)

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New insights into rodent brain microstructure and metabolism in hepatic encephalopathy

Jessie Julie Mosso

Type C hepatic encephalopathy (HE) is a severe neuropsychiatric complication of chronic liver disease, for which the prognosis is poor in the absence of liver transplantation. Cirrhosis in type C HE leads to a toxic accumulation of ammonia in the blood, wh ...

EPFL2023

Interrelation between cardiac and brain small-vessel disease: a pilot quantitative PET and MRI study

Bénédicte Marie Maréchal, Ricardo Alberto Corredor Jerez

Background: Small-vessel disease (SVD) plays a crucial role in cardiac and brain ischemia, but little is known about potential interrelation between both. We retrospectively evaluated 370 patients, aiming at assessing the interrelation between cardiac and ...

London2023

Early Neuroprotective Effects of Bovine Lactoferrin Associated with Hypothermia after Neonatal Brain Hypoxia-Ischemia in Rats

Yohan Van de Looij

Neonatal hypoxic-ischemic (HI) encephalopathy (HIE) in term newborns is a leading cause of mortality and chronic disability. Hypothermia (HT) is the only clinically available therapeutic intervention; however, its neuroprotective effects are limited. Lacto ...

Basel2023

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Following traumatic brain injury (TBI), cerebral metabolic dysfunction, characterized by an elevated cerebral microdialysis (CMD) lactate/pyruvate (LP) ratio, is associated with poor outcome. However, the exact pathophysiological mechanisms underlying this ...

MARY ANN LIEBERT, INC2022

Cortical lesions, central vein sign, and paramagnetic rim lesions in multiple sclerosis: Emerging machine learning techniques and future avenues

Jean-Philippe Thiran, Meritxell Bach Cuadra, Tobias Kober, Cristina Granziera, Francesco La Rosa, Maxence Charles F Wynen

The current diagnostic criteria for multiple sclerosis (MS) lack specificity, and this may lead to misdiagnosis, which remains an issue in present-day clinical practice. In addition, conventional biomarkers only moderately correlate with MS disease progres ...

ELSEVIER SCI LTD2022

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Paramagnetic rim lesions (PRL) in multiple sclerosis are chronic inflammatory lesions depicted in susceptibility-based MRI where high PRL lesion burden has been associated with a more aggressive disease course. As their visual detection is subjective and t ...

ISMRM2021

Objective: Acute intracranial hypertension is an important risk factor of secondary brain damage after traumatic brain injury. Hypertensive episodes are often diagnosed reactively, leading to late detection and lost time for intervention planning. A pro-ac ...

IOP PUBLISHING LTD2020

Evaluating the potential of hyperpolarised [1-13C] L-lactate as a neuroprotectant metabolic biosensor for stroke

Mor-Miri Mishkovsky, Jean-Noël Hyacinthe, Mario Gaetano Lepore, Thanh Phong Kevin Lê, Lara Buscemi Estefanell

Cerebral metabolism, which can be monitored by magnetic resonance spectroscopy (MRS), changes rapidly after brain ischaemic injury. Hyperpolarisation techniques boost (13)C MRS sensitivity by several orders of magnitude, thereby enabling in vivo monitoring ...

2020

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Purpose To exploit the improved comparability and hardware independency of quantitative MRI, databases of MR physical parameters in healthy tissue are required, to which tissue properties of patients can be compared. In this work, normative values for long ...

WILEY2019

Systemic hypoxia-ischemia (HI) often occurs during preterm birth in human. HI induces injuries to hinder brain cells mainly in the ipsilateral forebrain structures. Such HI injuries may cause lifelong disturbances in the distant regions, such as the contra ...

2019