Publication
NAD(+) has emerged as a vital cofactor that can rewire metabolism, activate sirtuins, and maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded protein response. This improved understanding of NAD(+) metabolism revived interest in NAD(+)-boosting strategies to manage a wide spectrum of diseases, ranging from diabetes to cancer. In this review, we summarize how NAD(+) metabolism links energy status with adaptive cellular and organismal responses and how this knowledge can be therapeutically exploited.
Vassily Hatzimanikatis, Liliana Angeles Martinez
Johan Auwerx, Hao Li, Daniel Garcia
Johan Auwerx, Mario Romani, Elena Katsyuba, Dina Hofer