Publication
Accumulation of amino-polyvinyl alcohol-coated superparamagnetic iron oxide nanoparticles in bone marrow: implications for local stromal cells
Publications associées (33)
Characterization of the gut-bone marrow axis through bile acid signaling
Communication between the intestine and other organs such as the lungs, brain or bones is mediated by several metabolites, like short-chain fatty acids or bile acids, that relay information about nutritional and microbiota status. Bile acids are endogenous ...
EPFL2024Novel quantitative bioengineered tools to track human bone marrow niche cellular constituents in health and disease
Acute leukemia has a high mortality rate of approximately 50%, and current methods are not effective in predicting disease progression and relapse. To improve our understanding of hematopoiesis and develop new markers for predicting disease relapse in dead ...
EPFL2023Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis
Freddy Radtke, Ute Koch, Jialin Zhang, Soufiane Boumahdi
Self-renewal and differentiation of stem and progenitor cells are tightly regulated to ensure tissue homeostasis. This regulation is enabled both remotely by systemic circulating cues, such as cytokines and hormones, and locally by various niche-confined f ...
ELSEVIER2023Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function
Interaction with microenvironmental factors is crucial for the regulation of hematopoietic stem cell (HSC) function. Stroma derived factor (SDF)-1 alpha supports HSCs in the quiescent state and is central to the homing of transplanted HSCs. Here, we show t ...
CELL PRESS2022MarrowQuantAcross Aging and Aplasia: A Digital Pathology Workflow for Quantification of Bone Marrow Compartments in Histological Sections
Olaia Maria Naveiras Torres-Quiroga, Olivier Burri, Rita Sarkis, Nicolas Kunz, Vasco Ledebur de Antas de Campos, Josefine Catharina Pedersen Tratwal, Frédérica Schyrr, Chiheb Boussema, Daniel Naveed Tavakol, Shanti Rojas-Sutterlin
The bone marrow (BM) exists heterogeneously as hematopoietic/red or adipocytic/yellow marrow depending on skeletal location, age, and physiological condition. Mouse models and patients undergoing radio/chemotherapy or suffering acute BM failure endure rapi ...
2020Quantitative approaches to unravel bone marrow adipocyte site-specificity and its implication in hematopoiesis
Josefine Catharina Pedersen Tratwal
Over the last decade, bone marrow (BM) adipose tissue (BMAT) has emerged as a distinct adipose depot with unique metabolic properties and effects both in homeostasis and in the progression of disease.
We provide a first comprehensive review of existing an ...
EPFL2020PEG/HA Hybrid Hydrogels for Biologically and Mechanically Tailorable Bone Marrow Organoids
Nicolas Antoine Vincent Broguiere, Martin Ehrbar, Queralt Vallmajó Martín
Bone marrow (BM) organoids provide powerful tools to study the vital interplay between the BM microenvironment and resident cells. Current biomaterials, however, are limited in terms of versatility for independently studying the biochemical and biophysical ...
WILEY-V C H VERLAG GMBH2020Metabolic and microenvironmental strategies to accelerate hematopoietic recovery post-aplasia
Vasco Ledebur de Antas de Campos
The procedure-associated mortality rate of bone marrow transplantations (BMT) remains close to 25%. The BMT is therefore only indicated for life-threatening diseases, with no replacement of this technology to be expected in the foreseeable future. Modest i ...
EPFL2019Bioengineering human bone marrow models to elucidate the triggers of the stem cell niche
The bone marrow (BM) microenvironment, or niche, significantly affects behaviors of its resident stem cell populations. Disruptions in the BM niche contribute to a number of severe clinical pathologies. Discovery of novel therapeutic strategies for BM-rela ...
EPFL2019Programmable microencapsulation for enhanced mesenchymal stem cell persistence and immunomodulation
Berna Ayse Özkale Edelmann, Christina Myra Tringides
Mesenchymal stem cell (MSC) therapies demonstrate particular promise in ameliorating diseases of immune dysregulation but are hampered by short in vivo cell persistence and inconsistencies in phenotype. Here, we demonstrate that biomaterial encapsulation i ...
NATL ACAD SCIENCES2019