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Compartmentalized Microfluidics for In Vitro Alzheimer’s Disease Studies

Publications associées (37)

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Tissue engineering of the bladder

Catharina Adelöw

Stem cell use in bladder tissue engineering is a recently addressed area of investigation that has generated excitement as a novel way to restore and regenerate lost or damaged urinary bladder tissue. The remodelling of smooth muscle plays a significant ro ...

EPFL2009

3D multi-chamber fluidic systems for analysis of angiogenesis in biomaterials: development, characterization and applications

Carmen Bonvin

The cellular processes leading to capillary morphogenesis depend on external stimuli, in particular flow and morphogen gradients. Several devices have been designed to study these interactions in vitro. However, most of these devices allow a single experim ...

2009

A novel cell culture approach for tissue engineering based on surface expansion

Hicham Majd

Most tissue engineering approaches include the delivery of reparative cells to a damaged host tissue. Generally these cells are sought to be of a stem cell character since they retain a high potential for proliferation and differentiation into diverse phen ...

EPFL2008

The goals of tissue engineering include recapitulating specific tissue functions for regenerative medicine and developing in vitro models of human tissues to study human physiology and pathophysiology and for testing and screening drugs before expensive cl ...

EPFL2008

Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parkinsons disease

Romain Zufferey

Neural stem cells (NSCs) are widely endorsed as a cell source for replacement strategies in neurodegenerative disease. However, their usefulness is currently limited by the inability to induce specific neurotransmitter phenotypes in these cells. In order t ...

Oxford University Press2008

Molecular heterogeneity of the ganglionic eminence and its relationship to the birth of neocortical interneurons

Susan Willi Monnerat

Neocortical function and malfunction depends critically on a spectrum of inhibitory interneurons. To gain novel insight in normal brain function and mechanisms leading to diseases, such as epilepsy or schizophrenia, the knowledge about the specific functio ...

EPFL2007

Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) com-bined with magnetic resonance imaging (MRI) are under clinical evaluation to enhance detection of neurodegenerative diseases. A major improvement would be to link therapeutic drugs to the SPIONs to a ...

2006

The correlation between neurodegenerative disease and protein aggregation in the brain has long been recognized, but a causal relationship has not been unequivocally established, in part because a discrete pathogenic aggregate has not been identified. The ...

2006

In this contribution we present the development of three microfabricated devices for the study of neuronal and cellular networks. Together, these devices form an attractive toolbox, which is useful to stimulate and record signals of both electrical and che ...

2006

In this study, we present the development and the characterization of a generic platform for cell culture able to monitor extracellular ionic activities (K+, NH4 +) for real-time monitoring of cell-based responses, such as necrosis, apoptosis, or different ...

2006