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Open channel-based microchip electrophoresis interfaced with mass spectrometry via electrostatic spray ionization

Publications associées (35)

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Miniaturized analytical systems for mass spectrometry-based protein studies

Mélanie Abonnenc

Current proteomic strategies depend strongly on the development of analytical methodologies and instrumentation. In parallel to the development of mass spectrometry (MS) - based proteomic workflows, microfluidic devices emerged in this field as a flexible ...

EPFL2009

Microfabricated out-of-plane arrays of integrated capillary nano-electrospray emitters

Herbert Shea, Renato Krpoun

We present the fabrication and operation of an integrated nano-electrospray thruster consisting of an array of microfabricated silicon capillary emitters and microfabricated silicon extractor electrodes. Based on previous work in which we showed operation ...

2009

Microfabricated out-of-plane arrays of integrated capillary nano-electrospray emitters

Herbert Shea, Renato Krpoun

This paper presents the fabrication and operation of an integrated nano-electrospray thruster consisting of an array of microfabricated silicon capillary emitters and microfabricated silicon extractor electrodes. Based on previous work in which we showed o ...

2009

Electrospray ionization mass spectrometry

Michel Prudent

Metal ions are essential elements in all living systems. Their detections and identifications in biological processes require different methodologies. Mass spectrometry is one of the commonly used techniques in bioinorganic analyses to fulfill these requir ...

EPFL2009

Functional Electrospray Emitters

Hubert Girault, Michel Prudent

Electrospray ionisation (ESI) is a soft technique used in mass spectrometry (MS) analysis able to introduce a wide variety of analytes in the gas phase. Briefly, it consists in the application of a high- voltage to a solution to spray it through a small or ...

2009

Microfluidic enzymatic reactors for proteome research

Hubert Girault

The field of proteomics has emerged as a valuable analytical tool for elucidating cellular and biological systems at the molecular level. As there is an ever-growing demand for new highly automated, high-throughput, and sensitive analytical tools, a key ch ...

2008

Biphasic Electrospray Ionization for the Study of Interfacial Complexes

Hubert Girault, Manuel Alejandro Méndez Agudelo, Michel Prudent

Biphasic electrospray ionization (BESI) mass spectrometry is achieved by using a dual-channel microsprayer, where channels filled with different immiscible phases meet at the Taylor cone. Two types of interfacial complexation reactions have been studied: t ...

The Japan Society of Analytical Chemistry / The Japan Society for Analytical Chemistry2008

Microfluidic front-end technologies for protein electrospray mass spectrometry

Niels Erik Lion

In the present work, a polymer microfabricated microsprayer is characterised and tested for the mass spectrometric analysis of biomolecules, in particular in the context of protein mass spectrometry and proteomics. As the core of this work deals with analy ...

EPFL2006

Characterization of a microfluidic dispensing system for localised stimulation of cellular networks

Nico de Rooij

We present a 3-D microfluidic device designed for localized drug delivery to cellular networks. The device features a flow cell comprising a main channel for nutrient delivery as well as multiple channels for drug delivery. This device is one key component ...

2006

Mechanical control of fluids in micro-analytical devices

Hubert Girault, Joël Rossier, Xiaoxia Bai

An apparatus for manipulating fluid samples comprises a micro-chip device having first and second covered channels, each channel having openings at both ends. The channels intersect to form a common intersection. Three of the openings of the channels are c ...

2006