Publication
Ion coalescence in Fourier transform mass spectrometry: should we worry about this in shotgun proteomics?
Publications associées (49)
Adding Color to Mass Spectra of Biopolymers: Charge Determination Analysis (CHARDA) Assigns Charge State to Every Ion Peak
Yury Tsybin, Natalia Gasilova, Laure Menin, Anton Kozhinov, Konstantin Nagornov
Traditionally, mass spectrometry (MS) output is the ion abundance plotted versus the ionic mass-to-charge ratio m/z. While employing only commercially available equipment, Charge Determination Analysis (CHARDA) adds a third dimension to MS, estimating for ...
Amer Chemical Soc2024Nonlinear kinetic simulation study of the ion-ion streaming instability in single- and multi-ion species plasmas
The nonlinear evolution of the ion-ion streaming instability (IISI) is studied using numerical techniques novel to this problem that afford direct insight into the evolution of the particle distributions of each species. During the linear phase of the inst ...
AMER INST PHYSICS2021Online Aerosol Chemical Characterization by Extractive Electrospray Ionization-Ultrahigh-Resolution Mass Spectrometry (EESI-Orbitrap)
Current mass spectrometry techniques for the online measurement of organic aerosol (OA) composition are subjected to either thermal/ionization-induced artifacts or limited mass resolving power, hindering accurate molecular characterization. Here, we combin ...
AMER CHEMICAL SOC2020Transient-mediated simulations of FTMS isotopic distributions and mass spectra to guide experiment design and data analysis
Yury Tsybin, Natalia Gasilova, Laure Menin, Anton Kozhinov, Konstantin Nagornov
Fourier transform mass spectrometry (FTMS) applications require accurate analysis of extremely complex mixtures of species in a wide mass and charge state ranges. To optimize the related FTMS data analysis accuracy, parameters for data acquisition and the ...
2020Ultraviolet Photodissociation of Peptides: New Insight on the Mobile Proton Model
Aleksandr Pereverzev, Elizaveta Solovyeva
In this work, we study the mechanism of peptide photodissociation by ultraviolet irradiation at 193 nm wavelength and discuss the role of ionization proton in this process. We found that substituting the ionization proton for the alkali metal cations (sodi ...
PLEIADES PUBLISHING INC2020Device and Method for Ion Cyclotron Resonance Mass Spectrometry
Yury Tsybin, Anton Kozhinov, Konstantin Nagornov
The present invention relates to a method and device for measuring m/z ratios of ions in ion cyclotron resonance (ICR) mass spectrometry. The described ion traps for ICR mass spectrometry are distinct from the previous configurations by having one or many ...
2017Novel Approaches in Cold Ion Spectroscopy for Structural Characterization of Biomolecules in the Gas Phase
Mass spectrometry is a powerful analytical technique, which has become invaluable across a wide range of scientific fields, such as "omics" sciences (e.g., proteomics), doping control and forensic sciences, drug development, environmental analysis, geologi ...
EPFL2016Method and apparatus for the analysis of molecules using mass spectrometry and optical spectroscopy
Vladimir Kopysov, Oleg Boyarkine
A method of analyzing molecules enabling chemical, structural and isomeric or conformational identification of the molecules, particularly in a stream from a chromatographic separation, comprising: generating ions from a sample of molecules to be analyzed; ...
2016Time-dependent frequency of ion motion in Fourier transform mass spectrometry
Recent experimental and theoretical findings suggest that the concept of time-dependent instantaneous frequency(IF) is required to comprehensively describe ion motion and mass spectra generation in Fourier transform mass spectrometry (FTMS). Here, we deriv ...
Elsevier Science Bv2015Fourier transform mass spectrometry at the uncertainty principle limit for improved qualitative and quantitative molecular analyses
Nowadays, among the instrumentation park of mass spectrometry, Fourier transform mass spectrometers (FTMS), including ion cyclotron resonance (ICR) and Orbitrap FTMS, provide the highest analytical performance for accurate measurements and mass resolution. ...
EPFL2015