Analysis of Translation Elongation Dynamics in the Context of an Escherichia coli Cell
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Several important societal and economic world problems can be addressed by the smart use of technology. The last forty years have witnessed the realization of computational systems and networks, rooted in our ability of crafting complex integrated circuits ...
Several important societal and economic world problems can be addressed by the smart use of technology. The last forty years have witnessed the realization of computational systems and networks, rooted in our ability of crafting complex integrated circuits ...
Protein synthesis is one of the central elements in every living cell. For this process, mRNAs coding for genes are simultaneously competing for the same translation machinery (ribosomes and amino acids). But the ultimate determinants of cellular functions ...
Translation is a central cellular process and the complexity of its mechanism necessitates mathematical frameworks to better understand system properties and make quantitative predictions. We have developed a gene sequence-specific mechanistic model for tr ...
Time-delays are common in many physical and biological systems and they give rise to complex dynamic phenomena. The elementary processes involved in template biopolymerization, such as mRNA and protein synthesis, introduce significant time delays. However, ...
With the recent advances in genomic, transcriptomic and proteomic technologies, it is now possible to measure the changes in the levels of all mRNAs and proteins in the cell, under different environmental and genetic perturbations. The large amts. of data ...
A comparative study of the compositional properties of various protein sets from both cellular and viral organisms is presented. Invariants and contrasts of amino acid usages have been discerned for different protein function classes and for different spec ...
The sequencing of genomes of several organisms and advances in high throughput technologies for transcriptome and proteome anal. has allowed detailed mechanistic studies of transcription and translation using math. frameworks that allow integration of both ...
The genetic information in DNA is transcribed to mRNA and then translated to proteins, which form the building blocks of life. Translation, or protein synthesis, is hence a central cellular process. We have developed a gene-sequence-specific mechanistic mo ...
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