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Producing Radical-Free Hyperpolarized Perfusion Agents for In Vivo Magnetic Resonance Using Spin-Labeled Thermoresponsive Hydrogel

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Methods for Molecular Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy using Hyperpolarized Nuclei

Riccardo Balzan

Since the introduction 10 years ago of the dissolution method, Dynamic Nuclear Polarization (DNP) became a widely applied and powerful technique to enhance nuclear magnetic resonance (NMR) signals of low naturally abundant, insensitive nuclear spins for an ...

EPFL2013

Method for nuclear magnetic resonance (NMR) spectroscopy measurements using long-lived coherences (LLC)

Geoffrey Bodenhausen, Paul Romeo Vasos, Riddhiman Sarkar, Puneet Ahuja

A method for nuclear magnetic resonance (NMR) spectroscopy of a sample comprises preparation of the sample and carrying out an NMR spectroscopy measurement. Preparation includes excitation of long lived coherences (LLC) between the singlet state S0 and the ...

2013

Understanding the molecular determinants underlying protein function requires the characterization of both structure and dynamics at atomic resolution. Nuclear relaxation rates allow a precise characterization of protein dynamics at the Larmor frequencies ...

American Chemical Society2013

Automated transfer and injection of hyperpolarized molecules with polarization measurement prior to in vivo NMR

Mor-Miri Mishkovsky, Tian Cheng, Arnaud Comment, Josefina Adriana Maria Bastiaansen

Hyperpolarized magnetic resonance via dissolution dynamic nuclear polarization necessitates the transfer of the hyperpolarized molecules from the polarizer to the imager prior to in vivo measurements. This process leads to unavoidable losses in nuclear pol ...

2013

We show that dynamic nuclear polarization (DNP) can be used to enhance NMR signals of C-13 and Si-29 nuclei located in mesoporous organic/inorganic hybrid materials, at several hundreds of nanometers from stable radicals (TOTAPOL) trapped in the surroundin ...

American Chemical Society2013

Transverse Relaxation of Scalar Coupled Protons in Magnetic Resonance of Non-Deuterated Proteins

Geoffrey Bodenhausen

The transverse relaxation rates R (2) = 1/T (2) of protons can be determined by spin-echo sequences with multiple refocusing pulses using moderate radio-frequency field strengths and properly chosen inter-pulse delays so as to suppress echo modulations due ...

Springer Vienna2012

[U(TpMe2)2I] exhibits at low temperatures single molecule magnet (SMM) behaviour comparable to its bipyridine derivative and related single ion U(iii) complexes recently reported as SMMs. The trend of variation of the energy barrier for the magnetic relaxa ...

2012

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Although nuclear magnetic resonance (NMR) can provide a wealth of information, it often suffers from a lack of sensitivity. Dynamic Nuclear Polarization (DNP) provides a way to increase the polarization and hence the signal intensities in NMR spectra by tr ...

Schweizerische Chemische Gesellschaft2012

A major challenge in cancer biology is to monitor and understand cancer metabolism in vivo with the goal of improved diagnosis and perhaps therapy. Because of the complexity of biochemical pathways, tracer methods are required for detecting specific enzyme ...

2011

Extending Timescales and Narrowing Linewidths in NMR

Geoffrey Bodenhausen, Aurélien Bornet, Pascal Miéville, Sami Jannin, Diego Carnevale, Paul Romeo Vasos, Simone Ulzega, Marc Anthony Caporini, Nicola Salvi, Martial Rey

Among the different fields of research in nuclear magnetic resonance (NMR) which are currently investigated in the Laboratory of Biomolecular Magnetic Resonance (LRMB), two subjects that are closely related to each other are presented in this article. On t ...

Schweizerische Chemische Gesellschaft2011