Wireless Monitoring of Endogenous and Exogenous Biomolecules on an Android Interface

Monitoring patients in intensive care units is generally expensive and time consuming. A prompter medical intervention for those critical patients is a key factor for their safety. Therefore, a system that offers immediate visualization of the monitored data represents a great advance in the field. In this paper, the design, the development, and the validation of an android interface for the continuous and wireless monitoring of up to five compounds are described. Continuous monitoring of the biomolecules is addressed by using a fully integrated hardware platform consisting of biosensors connected to a read-out circuit on a printed circuit board. The electrochemical platform uses Roving's Bluetooth module RN-42 to send the measured data to the mobile device. For the validation of the system, some biomolecules are taken as reference: glucose and lactate for endogenous metabolites and paracetamol for exogenous biomolecules. Chronoamperometries are performed at +650 mV for glucose and lactate and at +450 mV for paracetamol. Multi-walled carbon nanotubes are deposited on working electrodes for glucose and lactate for enhanced signal. Instead, for paracetamol, bare working electrodes are used. The measured data are continuously displayed on the screen of the mobile device because of the android interface. Current step for every variation of glucose, lactate, or paracetamol is clearly visible by the trend of the graphs.