Publication
The Role of Lipid Competition for Endosymbiont-Mediated Protection against Parasitoid Wasps in Drosophila
Publications associées (35)
Infection Dynamics and Immune Response in a Newly Described Drosophila-Trypanosomatid Association
Bruno Lemaitre, Anna Dostalova
Trypanosomatid parasites are significant causes of human disease and are ubiquitous in insects. Despite the importance of Drosophila melanogaster as a model of infection and immunity and a long awareness that trypanosomatid infection is common in the genus ...
American Society for Microbiology2015Methods to study Drosophila immunity
Bruno Lemaitre, Olivier Binggeli, Andrew Jonathan Bretscher
Innate immune mechanisms are well conserved throughout evolution, and many theoretical concepts, molecular pathways and gene networks are applicable to invertebrate model organisms as much as vertebrate ones. Drosophila immunity research benefits from an e ...
Elsevier2014Insect endosymbiont proliferation is limited by lipid availability
Bruno Lemaitre, Juan Camilo Paredes Escobar, Jeremy Keith Herren
Spiroplasma poulsonii is a maternally transmitted bacterial endosymbiont that is naturally associated with Drosophila melanogaster. S. poulsonii resides extracellularly in the hemolymph, where it must acquire metabolites to sustain proliferation. In this s ...
Elife Sciences Publications Ltd2014Understanding the role of antibodies in murine infections with Heligmosomoides (polygyrus) bakeri: 35 years ago, now and 35 years ahead
The rodent intestinal nematode H.p.bakeri has played an important role in the exploration of the host–parasite relationship of chronic nematode infections for over six decades, since the parasite was first isolated in the 1950s by Ehrenford. It soon became ...
Wiley-Blackwell2014The contribution of the host stress response to the pathogenesis of Pseudomonas entomophila in the Drosophila intestine
Recently, several studies done in Drosophila have revealed that efficient and rapid recovery from bacterial infection in the gut is possible only when bacterial clearance by the immune system is coordinated with repair through renewal of the epithelium dam ...
EPFL2013Cultivating endosymbionts—Host environmental mimics support the survival of Symbiodinium C15 ex hospite
Sustaining in vitro cultures of endosymbiotic dinoflagellates in the genus Symbiodinium is important, addressing questions relating to Symbiodinium function and Symbiodinium dependent host fitness. Difficulties in establishing representative Symbiodinium c ...
Elsevier2012Loss of reproductive parasitism following transfer of male-killing Wolbachia to Drosophila melanogaster and Drosophila simulans
Wolbachia manipulate insect host biology through a variety of means that result in increased production of infected females, enhancing its own transmission. A Wolbachia strain (wInn) naturally infecting Drosophila innubila induces male killing, while nativ ...
Nature Publishing Group2012Spiroplasma and host immunity: activation of humoral immune responses increases endosymbiont load and susceptibility to certain Gram-negative bacterial pathogens in Drosophila melanogaster
Bruno Lemaitre, Jeremy Keith Herren
Spiroplasma poulsonii and its relatives are facultative, vertically transmitted endosymbionts harboured by several Drosophila species. Their long-term survival requires not only evasion of host immunity, but also that Spiroplasma does not have a net detrim ...
2011Negative Regulation by Amidase PGRPs Shapes the Drosophila Antibacterial Response and Protects the Fly from Innocuous Infection
Bruno Lemaitre, Juan Camilo Paredes Escobar, David Welchman
Peptidoglycan recognition proteins (PGRPs) are key regulators of insect immune responses. In addition to recognition PGRPs, which activate the Toll and Imd pathways, the Drosophila genome encodes six catalytic PGRPs with the capacity to scavenge peptidogly ...
2011Dpp Signaling Activity Requires Pentagone to Scale with Tissue Size in the Growing Drosophila Wing Imaginal Disc
The wing of the fruit fly, Drosophila melanogaster, with its simple, two-dimensional structure, is a model organ well suited for a systems biology approach. The wing arises from an epithelial sac referred to as the wing imaginal disc, which undergoes a pha ...
2011