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New insights into ROS dynamics: a multi-layered microfluidic chip for ecotoxicological studies on aquatic microorganisms
Publications associées (34)
Adolescent Stress-Induced Ventral Hippocampus Redox Dysregulation Underlies Behavioral Deficits and Excitatory/Inhibitory Imbalance Related to Schizophrenia
Maria del Carmen Sandi Perez, Dogukan Hazar Ülgen, Thamyris Silva
Background and hypothesis: Redox dysregulation has been proposed as a convergent point of childhood trauma and the emergence of psychiatric disorders, such as schizophrenia (SCZ). A critical region particularly vulnerable to environmental insults during ad ...
2024HaloTag-Based Tools for Live-Cell Imaging and Elucidation of Organellar Redox Biology
Redox homeostasis is a key factor in maintaining cellular function and health. The main determinant of the intracellular redox potential is ubiquitous glutathione (GSH) together with its oxidized dimer (GSSG). Importantly, both redox equilibrium and GSH ho ...
EPFL2024Monitoring On-Target Signaling Responses in Larval Zebrafish- Z-REX Unmasks Precise Mechanisms of Electrophilic Drugs and Metabolites
Yimon Aye, Phillippe Ly, Jesse Poganik, Kuan-Ting Huang
Reactive metabolites and related electrophilic drugs are among the most challenging small molecules to study. Conventional approaches to deconstruct the mode of action (MOA) of such molecules leverage bulk treatment of experimental specimens with an excess ...
JOURNAL OF VISUALIZED EXPERIMENTS2023Title: "Labels Matter: Is it stress or is it Trauma?"
In neuroscience, the term 'Stress' has a negative connotation because of its potential to trigger or exacerbate psychopathologies. Yet in the face of exposure to stress, the more common reaction to stress is resilience, indicating that resilience is the ru ...
SPRINGERNATURE2021Programming effects of peripubertal stress on spatial learning
Maria del Carmen Sandi Perez, Stamatina Tzanoulinou, Cristina Marquez Vega
Exposure to adversity during early life can have profound influences on brain function and behavior later in life. The peripubertal period is emerging as an important time-window of susceptibility to stress, with substantial evidence documenting long-term ...
2020Locomotion in virtual environments predicts cardiovascular responsiveness to subsequent stressful challenges
Maria del Carmen Sandi Perez, Nathalie Heidi Meyer, João Pedro de Matos Rodrigues, Stephan Streuber, Erik Hans Jakob Studer
Individuals differ in their physiological responsiveness to stressful challenges, and stress potentiates the development of many diseases. Heart rate variability (HRV), a measure of cardiac vagal break, is emerging as a strong index of physiological stress ...
2020Renal Purge of Hemolymphatic Lipids Prevents the Accumulation of ROS-Induced Inflammatory Oxidized Lipids and Protects Drosophila from Tissue Damage
Bruno Lemaitre, Samuel Rommelaere, Xiaoxue Li
Animals require complex metabolic and physiological adaptations to maintain the function of vital organs in response to environmental stresses and infection. Here, we found that infection or injury in Drosophila induced the excretion of hemolymphatic lipid ...
2020Anisotropic behaviour of shallow opalinus clay
Lyesse Laloui, Alessio Ferrari, Eleonora Crisci, Alberto Minardi
Opalinus Clay shale, the selected host geomaterial of a high-level radioactive waste repository in Switzerland, was sourced at shallow depth in a borehole in the northern part of the country. Pairs of specimens, retrieved from the same depth were prepared ...
Springer Verlag2019An energetic view of stress: Focus on mitochondria
Energy is required to sustain life and enable stress adaptation. At the cellular level, energy is largely derived from mitochondria – unique multifunctional organelles with their own genome. Four main elements connect mitochondria to stress: 1) Energy is r ...
2018Long term programming of psychopathology-like behaviors in male rats by peripubertal stress depends on individual’s glucocorticoid responsiveness to stress
Maria del Carmen Sandi Perez, Sophie Elizabeth Walker
Experience of adversity early in life and dysregulation of hypothalamus–pituitary–adrenocortical (HPA) axis activity are risk factors often independently associated with the development of psychopathological disorders, including depression, PTSD and pathol ...
2018