Enhanced Effective Connectivity Between Primary Motor Cortex and Intraparietal Sulcus in Well-Recovered Stroke Patients
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Background Each year, five million people are left disabled after stroke. Upper -extremity (UE) dysfunction is a leading problem. Neuroplasticity can be enhanced by non-invasive brain stimulation (NIBS) but evidence from large, randomized multicenter trial ...
Humans have a distinguishing ability for fine motor control that is subserved by a highly evolved cortico-motor neuronal network. The acquisition of a particular motor skill involves a long series of practice movements, trial and error, adjustment and refi ...
While humans are known to have several premotor cortical areas, secondary motor cortex (M2) is often considered to be the only higher -order motor area of the mouse brain and is thought to combine properties of various human premotor cortices. Here, we sho ...
Tourette syndrome is characterized by 'unvoluntary' tics, which are compulsive, yet often temporarily suppressible. The inferior frontal gyms is implicated in motor control, including inhibition of pre-potent actions through influences on downstream subcor ...
Motivated by the need for a better understanding of post-stroke recovery and new biomarkers to improve stroke patient stratification and outcomes, this thesis investigated structure-function coupling and its role in post-stroke recovery. Furthermore, in or ...
An important function of the brain is to interpret incoming sensory information from the outside world to guide adaptive behavior. Understanding how and where sensory information is transformed into motor commands in a context- and learning-dependent manne ...
Structural brain imaging has continuously furthered our knowledge how different pathways of the human motor system contribute to residual motor output in stroke patients. Tract-related microstructure of pathways between primary and premotor areas has been ...
Neuro-rehabilitative research is developing novel strategies to enhance the effectiveness of therapies after stroke by using a combination of physical and plasticizing treatments 1-3. Previous studies have shown that repeated optogenetics stimulation of ne ...
Hand motor function is often severely affected in stroke patients. Non-satisfying recovery limits reintegration into normal daily life. Understanding stroke-related network changes and identifying common principles that might underlie recovered motor funct ...
Introduction Unilateral movements are primarily processed in contralateral cortical and subcortical areas and additionally in ipsilateral cerebellum, leading to an asymmetric pattern of neural activation. Decrease of lateralization is characteristic of agi ...