Publication
Effect of media composition on bioavailability and toxicity of silver and silver nanoparticles in fish intestinal cells (RTgutGC)
Publications associées (37)
Two-generation common-garden experiment reveals a strong genetic contribution to migration tendency in brown trout (Salmo trutta)
Many salmonids, including brown trout (Salmo trutta), demonstrate alternative migration strategies under different environmental conditions, and as such, they are assumed to be predominantly facultative. Through experimental breeding for two generations, w ...
CANADIAN SCIENCE PUBLISHING2023Bio accessibility of tire-associated organic chemicals in fish gut (Oncorhynchus mykiss): insights from an in vitro digestion model
Kristin Schirmer, Florian Frédéric Vincent Breider, Benoît Jean Dominique Ferrari, Thibault Béranger Masset
Tire and Road Wear Particles (TRWP) account for an important part of the anthropogenic particles released into the environment. There are scientific knowledge gaps as to the potential bio accessibility of chemicals associated with TRWP to aquatic organisms ...
2022Azide-Containing Hypervalent Iodine Reagents for Biomolecules Functionalization
Raphaël Michel Henri Simonet-Davin
The goal of my PhD was the development of a new method for unselective surface labeling, not substrate-specific, that would give access to direct visualization of any surface interactions.In order to achieve this challenging goal, we wanted to develop a ge ...
EPFL2022Cytotoxicity, Accumulation and Translocation of Silver and Silver Sulfide Nanoparticles in contact with Rainbow Trout Intestinal Cells
Silver nanoparticles (Ag NPs) are widely used in consumer products especially because of their antimicrobial properties. However, this wide usage of Ag NPs is accompanied by their release into the environment where they will be rapidly transformed to other ...
ELSEVIER2021Covalent and Noncovalent Conjugation of Degradable Polymer Nanoparticles to T Lymphocytes
Harm-Anton Klok, Tanja Thomsen
Cells are attractive as carriers that can help to enhance control over the biodistribution of polymer nanomedicines. One strategy to use cells as carriers is based on the cell surface immobilization of the nanoparticle cargo. While a range of strategies ca ...
AMER CHEMICAL SOC2021A fish intestinal barrier model to assess the interaction with chemicals in vitro
The intestinal epithelium acts as vital gate keeper between the fish and its surrounding environment. A single layer of connected epithelial cells forms a selective barrier, which, among other essential functions, is important for nutrient uptake and defen ...
EPFL2019Fish-gut-on-chip: development of a microfluidic bioreactor to study the role of the fish intestine in vitro
Philippe Renaud, Kristin Schirmer, Carolin Drieschner
In this study we present the first fish-gut-on-chip model. This model is based on the reconstruction of the intestinal barrier by culturing two intestinal cell lines from rainbow trout, namely epithelial RTgutGC and fibroblastic RTgutF, in an artificial mi ...
2019Corncob Biorefinery for Platform Chemicals and Lignin Coproduction: Metal Chlorides as Catalysts
A facile approach to a corncob biorefinery, focusing on both carbohydrate valorization and lignin stabilization, was proposed to coproduce platform chemicals (glucose, xylose, arabinose, and furfural) and lignin. Different metal chloride prehydrolyses of c ...
AMER CHEMICAL SOC2019Investigation of nanoparticle-protein interactions with novel methods
Advancements in novel nanomaterials present promising avenue for therapeutics and diagnosis in nanomedicine. Importantly, in these applications, nanoparticles (NPs) are almost instantly coated with a complex layer of proteins in biological environment, ter ...
EPFL2018What is the role of fish intestine as environment-organism barrier? Mechanistic investigations using fish intestinal cells on a chip
The gut of fish belongs to the most essential barriers that mark the border between the organism and its surrounding environment. The pivotal barrier function, allowing to absorb nutrients from the diet while simultaneously protecting the organism from pat ...
EPFL2018