Publication
A brain-spine interface alleviating gait deficits after spinal cord injury in primates
Publications associées (109)
Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial
Grégoire Courtine, Jordan Squair, Markus Maximilian Rieger
Cervical spinal cord injury (SCI) leads to permanent impairment of arm and hand functions. Here we conducted a prospective, single-arm, multicenter, open-label, non-significant risk trial that evaluated the safety and efficacy of ARCEX Therapy to improve a ...
Nature Portfolio2024System for control of spasticity
Grégoire Courtine, Jocelyne Bloch, Robin Jonathan Demesmaeker, Fabien Bertrand Paul Wagner, Karen Minassian, Salif Axel Komi
The present invention relates to a neuromodulation/neurostimulation system (10) for the treatment of spasticity in a mammal, said system (10) comprising: - at least one control unit (12) configured and arranged to provide stimulation data, and - at least o ...
2024Brain-controlled spinal cord stimulation to restore mobility after spinal cord injury.
Spinal Cord Injury (SCI) affects almost 500,000 people every year, causing complete paralysis of both legs in severe cases, with no current treatment perspective. However, new neuroengineering technologies, such as the Brain Spine Interface (BSI), have eme ...
EPFL2023Closed-Loop Control of Epidural Electrical Stimulation in Patients with Spinal Cord Injury and Parkinson's Disease
Over the past two decades, epidural electrical stimulation (EES) has transitioned from a treatment for chronic pain to a promising paradigm for ameliorating deficits associated with neurological disorders like spinal cord injury (SCI) and Parkinson's Disea ...
EPFL2023Walking naturally after spinal cord injury using a brain-spine interface
Grégoire Courtine, Jocelyne Bloch, Léonie Asboth, Robin Jonathan Demesmaeker, Anne Marie Lucienne Watrin, Sergio Daniel Hernandez, Henri Charles Alexandre Lorach, Jimmy James Ravier, Grégory Didier Dumont, Félix Antoine Martel, Laure Coquoz, Valeria Spagnolo, Thibault Jean Etienne Collin, Icare Sakr, Lucas Struber, Salif Axel Komi, Molywan Vat, Carmina Andrea Galvez Solano, Edeny Baaklini, Cathal John Harte
A spinal cord injury interrupts the communication between the brain and the region of the spinal cord that produces walking, leading to paralysis(1,2). Here, we restored this communication with a digital bridge between the brain and spinal cord that enable ...
NATURE PORTFOLIO2023Targeted regeneration of spinal cord neurons across a complete injury restores walking
Spinal cord injury (SCI) interrupts axonal connections between the brain and the spinal cord, and is characterized by a spectrum of sensorimotor and autonomic impairments. While spontaneous recovery is limited, recent studies have shown that functional imp ...
EPFL2023Loss of Motor Cortical Inputs to the Red Nucleus after CNS Disorders in Nonhuman Primates
The premotor (PM) and primary motor (M1) cortical areas broadcast voluntary motor commands through multiple neuronal pathways, including the corticorubral projection that reaches the red nucleus (RN). However, the respective contribution of M1 and PM to co ...
SOC NEUROSCIENCE2023SiliFish: A desktop application to model swimming behavior in developing zebrafish (Danio rerio)
SiliFish is an open-source desktop application tomodel and study zebrafish swimming. Here, we explain how to define the general parameters of the model, define cell populations, place them within the spinal cord, and define their projections. We explain ho ...
Amsterdam2023A digital bridge between brain and spinal cord restores walking after paralysis
Grégoire Courtine, Jocelyne Bloch
Spinal-cord injury interrupts communication between the brain and spinal cord, leading to paralysis. An implant that decodes the brain signals that control movements and drives electrical stimulation of the spinal cord re-establishes this communication, en ...
NATURE PORTFOLIO2023