Publication
Miniaturized single-cell analyses for biomedical applications
Publications associées (61)
Immunosuppressive roles of Activin-A in melanoma and characterization of its precursor cleavage
Activin-A, a transforming growth factor êµ family member, is a pleiotropic cytokine with diverse functions in development, fertility, adult tissue homeostasis, and aging. Accordingly, deregulation of Activin-A signaling has been associated with many patho ...
EPFL2022Principles of checkpoint override
Why biological quality-control systems fail is often mysterious. Specifically, checkpoints such as the DNA damage checkpoint or the spindle assembly checkpoint are overriden after prolonged arrests allowing cells to continue dividing despite the continued ...
EPFL2022Mechanics of the cellular microenvironment as probed by cells in vivo during zebrafish presomitic mesoderm differentiation
Tissue morphogenesis, homoeostasis and repair require cells to constantly monitor their three-dimensional microenvironment and adapt their behaviours in response to local biochemical and mechanical cues. Yet the mechanical parameters of the cellular microe ...
2022Roles of Epigenetic Dysregulation in Cancer Progression and Metastasis
Nearly all the cells of an organism share the same DNA sequence or genome, and yet they show different phenotypes and carry out different functions. This diversity is made possible by a verity of molecular modifications acting on the DNA sequence that coll ...
EPFL2020Suspended microchannel resonators for Biosensing applications
A Suspended microchannel resonator (SMR) is composed by a hollow resonant structure containing embedded microfluidic channel. This device allows to circumvent the viscous damping confining the fluid to the inside of the resonant beam. The goal of this proj ...
2020Microfluidic devices for the study of cell-cell, cell-particle and particle-particle interactions
Margaux Catherine Marie Duchamp
Microfluidics and microtechnologies are of great interest for biological applications. This interest is linked to the fact that microtechnologies enable the study of single cells at the cellular and sub-cellular level. One of many applications of such sing ...
EPFL2020Ubiquitous macropinocytosis in anthozoans
Transport of fluids, molecules, nutrients or nanoparticles through coral tissues are poorly documented. Here, we followed the flow of various tracers from the external seawater to within the cells of all tissues in living animals. After entering the genera ...
2020Spatiotemporal pattern formation in E. coli biofilms explained by a simple physical energy balance
Anne-Florence Raphaëlle Bitbol
While the biofilm growth mode conveys notable thriving advantages to bacterial populations, the mechanisms of biofilm formation are still strongly debated. Here, we investigate the remarkable spontaneous formation of regular spatial patterns during the gro ...
Royal Society of Chemistry (RSC)2020Microfluidics as an Emerging Precision Tool in Developmental Biology
Microfluidics has become a precision tool in modern biology. It enables omics data to be obtained from individual cells, as compared to averaged signals from cell populations, and it allows manipulation of biological specimens in entirely new ways. Cells a ...
2019Cytosolic delivery and characterization of monobodies interfering with SH2 domain-phosphotyrosine interactions
Targeted cancer therapy is a very promising concept; however, small molecule inhibitors only exist for a limited number of oncoproteins and resistance development limits their clinical use. Different engineered non-antibody scaffolds are being explored to ...
EPFL2018