Repositioning approved drugs for the treatment of problematic cancers using a screening approach
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Ductal cells of the pancreas form the epithelial lining of the branched tubes that deliver enzymes produced by pancreatic acinar cells into the duodenum. In addition, these cells secrete bicarbonate that neutralizes stomach acidity. During development, epi ...
beta-catenin and Adenomatous poliposis coli (APC) have been implicated in non-ductal pancreatic cancers. As for many other organs, several recent publications show that beta-catenin and more largely the Wnt pathway appear to function at the level of pancre ...
To test and optimize photodynamic therapy of early cancers in the upper aero-digestive tract and esophagus, we sought an appropriate animal model, which was found in the 7,12-dimethylbenz[a]anthracene-induced early squamous cell carcinoma in the Golden Syr ...
The paper proposes a learning approach to support medical researchers in the context of in-vivo cancer imaging, and specifically in the analysis of Dynamic Contrast-Enhanced MRI (DCE-MRI) data. Tumour heterogeneity is characterized by identifying regions w ...
Doxorubicin has the widest spectrum of antitumor activity of all antineoplastic agents and is the most utilized anticancer drug worldwide. Unfortunately there are several tumor types that do not respond to doxorubicin and, furthermore, its effectiveness is ...
Head and neck (H&N) cancer patients have a high incidence of second primary tumors in the tracheobronchial tree. Diagnostic autofluorescence endoscopy (DAFE) has shown promising results in the detection of early neoplastic and pre-neoplastic changes in the ...
The discovery of the anticancer properties of cisplatin in 1965 heralded the development of metallopharmaceuticals and founded a revolution in cancer therapy. Platinum drugs are believed to induce cytotoxicity by cross-linking DNA, causing changes to the D ...
The antitumor activity of the organometallic ruthenium(II)-arene mixed phosphine complexes, [Ru(h6-p-cymene)Cl(PTA)(PPh3)]BF4 1b and [Ru(h6-C6H5CH2CH2OH)Cl(PTA)(PPh3)]BF4 2b (PTA = 1,3,5-triaza-7-phosphaadamantane), have been evaluated in vitro and compare ...