Publication
Pharmacological stimulation to facilitate and restore standing and walking functions in spinal cord motor disorders
Publications associées (32)
Walking naturally after spinal cord injury using a brain-spine interface
Grégoire Courtine, Jocelyne Bloch, Léonie Asboth, Robin Jonathan Demesmaeker, Anne Marie Lucienne Watrin, Sergio Daniel Hernandez, Henri Charles Alexandre Lorach, Jimmy James Ravier, Grégory Didier Dumont, Félix Antoine Martel, Laure Coquoz, Valeria Spagnolo, Thibault Jean Etienne Collin, Icare Sakr, Lucas Struber, Salif Axel Komi, Molywan Vat, Carmina Andrea Galvez Solano, Edeny Baaklini, Cathal John Harte
A spinal cord injury interrupts the communication between the brain and the region of the spinal cord that produces walking, leading to paralysis(1,2). Here, we restored this communication with a digital bridge between the brain and spinal cord that enable ...
NATURE PORTFOLIO2023Closed-Loop Control of Epidural Electrical Stimulation in Patients with Spinal Cord Injury and Parkinson's Disease
Over the past two decades, epidural electrical stimulation (EES) has transitioned from a treatment for chronic pain to a promising paradigm for ameliorating deficits associated with neurological disorders like spinal cord injury (SCI) and Parkinson's Disea ...
EPFL2023Neuromodulation/neurostimulation system for mitigating locomotor deficits of parkinson's disease, spinal cord injury (sci), stroke and/or other neurological disorders
Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Jordan Squair, Léonie Asboth, Tomislav Milekovic, Robin Jonathan Demesmaeker
The present invention relates to a combined neuromodulation and/or neurostimulation system (10) for mitigating locomotor deficits of/or neuronal disorders, especially Parkinson's disease, said system (10) comprising: - at least one Deep Brain Stimulation ( ...
2023Personalizable computational models of electrical spinal cord stimulation to restore function after neurological disorders
Spinal Cord Injury (SCI) disrupts the communication between the brain and spinal circuits below the lesion, leading to a plethora of neurological impairments, including the loss of motor function. At present, the only medical practices to enhance recovery ...
EPFL2021Electrical spinal cord stimulation protocols to regulate motor and autonomic functions in people with neurological disorders
Neurological disorders such as spinal cord injury (SCI) massively reduce independence and quality of life. Most often, the majority of the nervous system is still fully or partially spared, but dysfunctional due to aberrant or absent descending input from ...
EPFL2021System and method for control of autonomic function
Grégoire Courtine, Jordan Squair
A system (10) for neuromodulation and/or neurostimulation, for the treatment of a mammal, at least comprising: - at least one control unit (12) configured and arranged to provide stimulation data; - at least one stimulation unit (14) configured and arrange ...
2020Spatiotemporal stimulation strategies in neuroprostheses to improve locomotion after spinal cord injury
Spinal cord injury (SCI) disrupts communication within central nervous system and lead to range of neurological disorders including paralysis. Current rehabilitation strategies to restore locomotion are poorly effective in people with severe SCI. Epidural ...
EPFL2019Non-invasive, Brain-controlled Functional Electrical Stimulation for Locomotion Rehabilitation in Individuals with Paraplegia
Mohamed Bouri, Solaiman Shokur, Miguel Nicolelis
Spinal cord injury (SCI) impairs the flow of sensory and motor signals between the brain and the areas of the body located below the lesion level. Here, we describe a neurorehabilitation setup combining several approaches that were shown to have a positive ...
2019Brain-spine interface technologies to alleviate gait deficits after Parkinson's disease
Gait and balance deficits are motor disabilities that typically develop late in the progression of Parkinson's disease (PD). These deficits are thought to be the result of dysregulated neural activity in the cortico-basal ganglia-thalamic-cortical motor lo ...
EPFL2019Neuromodulation in the restoration of function after spinal cord injury
Neuromodulation, the use of electrical interfaces to alter neuronal activity, has been successful as a treatment approach in several neurological disorders, including deep brain stimulation for Parkinson's disease and epidural spinal stimulation for chroni ...
2018