Means and methods for bioluminescence resonance energy transfer (bret) analysis in a biological sample
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We present the architecture and three applications of the largest resolution image sensor based on single-photon avalanche diodes (SPADs) published to date. The sensor, fabricated in a high-voltage CMOS process, has a resolution of 512 x 128 pixels and a p ...
This work describes different strategies for the detection of biologically relevant analytes. The main goal was to achieve sensing in water, which is a prerequisite for application to real biological samples. In several cases, we could demonstrate that our ...
This paper presents an on-chip, filter-less fluorescence detector using an all-digital, time-resolved imager based on a CMOS single-photon detector array with limited in situ processing. The device comprises an array of pixels capable of detecting single p ...
The design and characterization of an imaging sensor based on single photon avalanche diodes is presented. The sensor was fully integrated in a 0.35µm CMOS technology. The core of the imager is an array of 4x112 pixels that independently and simultaneously ...
We show that we can effectively fit complex animation models to noisy image data. Our approach is based on robust least squares adjustment and takes advantage of three complementary sources of information: stereo data, silhouette edges and 2D feature point ...
An all-digital, time-gated 128x128 CMOS image sensor for on-chip fluorescence detection is presented. The sensor pixel consists of a single-photon avalanche diode (SPAD), time gating circuitry and a 1bit memory. The sensor allows on-chip fluorescence detec ...
This paper presents our work on a 65k pixel single-photon avalanche diode (SPAD) based imaging sensor realized in a 0.35 mu m standard CMOS process. At a resolution of 512 by 128 pixels the sensor is read out in 6.4ps to deliver over 150k monochrome frames ...