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The design of efficient ligands remains a key challenge in drug discovery. In the quest for lead-like ligands for the FK506-binding protein 51 (FKBP51), we designed two new classes of bicyclic sulfonamides to probe the contribution of conformational energy ...
Amer Chemical Soc2013
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We advocate a compressed sensing strategy that consists of multiplying the signal of interest by a wide bandwidth modulation before projection onto randomly selected vectors of an orthonormal basis. Firstly, in a digital setting with random modulation, con ...
Institute of Electrical and Electronics Engineers2012
A readout method which is suitable for high-density active microelectrode arrays used in electrophysiology experiments is presented. Amplitude modulation of consecutive channels enables simultaneous recording and transmission of the signals recorded on mul ...
An innovative readout channel, based on analog amplitude modulation of the signals recorded by each sensing site, is developed for high-density CMOS-based microelectrode arrays. A single amplification stage simultaneously records the neural activity acquir ...
2010
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An increase in Dynamic Nuclear Polarization (DNP) signal intensity is obtained with a tunable gyrotronproducing frequency modulation around 260 GHz at power levels less than 1W. The sweep rate of frequency modulation can reach 14 kHz, and its amplitude is ...
Academic Press Inc Elsevier Science2016
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The invention relates to the field of in vitro detection methods using luminescence. Provided is a sensor molecule for detecting an analyte of interest in a sample using bioluminescence resonance energy transfer (BRET), the sensor molecule comprising a pro ...
2016
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Stationary and localized Brillouin dynamic gratings are generated using phase modulation of both pump waves by a pseudo-random bit sequence. The gratings are applied to long variable delay of pulses and to cm-level distributed sensing ...
Azobenzenes have attracted great interest in recent years because of their ability to change conformation upon irradiation. This property has been featured in several applications not only in organic chemistry but also in biology. Even though monoazobenzen ...
2011
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The spectral broadening of the pump pulse through self phase modulation in a time domain distributed Brillouin sensor is demonstrated to have a non-negligible detrimental effect, leading to a doubling of the effective gain linewidth after some 20 km in sta ...
The International Society for Optical Engineering2010
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The present invention exploits the combination of the amplification, provided by the integration of a FET (or any other three terminal active device), with the signal modulation, provided by the MEM resonator, to build a MEM resonator with built-in transis ...
