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Breathe in and straighten your back: Hypoxia, notch, and scoliosis

Publications associées (32)

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Integrating Defect Data, Code Review Data, and Version Control Data for Defect Analysis and Prediction

Tao-Chun Lee

In this thesis, we present a new approach to integrating software system defect data: Defect reports, code reviews and code commits. We propose to infer defect types by keywords. We index defect reports into groups by the keywords found in the descriptions ...

2013

Notch Signaling Regulates Follicular Helper T Cell Differentiation

Freddy Radtke, Ute Koch, Anne Wilson, Nicolas Fasnacht, Floriane Auderset

Follicular helper T (TFH) cells are specialized in providing help for B cell differentiation and Ab secretion. Several positive and negative regulators of TFH cell differentiation have been described but their control is not fully understood. In this study ...

American Association of Immunologists2013

Background: The Notch signaling pathway plays complex roles in developing lungs, including regulation of proximodistal fates, airway cell specification and differentiation. However, the specific Notch-mediated signals involved in lung development remain un ...

Wiley-Blackwell2013

Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome

Freddy Radtke

The Notch signaling pathway is an important contributor to the development and homeostasis of the cardiovascular system. Not surprisingly, mutations in Notch receptors and ligands have been linked to a variety of hereditary diseases that impact both the he ...

Company of Biologists2012

Extracellular signals in development, physiology, homeostasis and disease often act by regulating transcription. Herein we describe a general method and specific resources for determining where and when such signaling occurs in live animals and for systema ...

Company Of Biologists Ltd2012

Inhibition of Fibroblast Growth by Notch1 Signaling Is Mediated by Induction of Wnt11-Dependent WISP-1

Freddy Radtke, Jialin Zhang, Yurong Tan

Fibroblasts are an integral component of stroma and important source of growth factors and extracellular matrix (ECM). They play a prominent role in maintaining tissue homeostasis and in wound healing and tumor growth. Notch signaling regulates biological ...

Public Library of Science2012

The Intestinal Epithelium

Luca Pellegrinet

The mammalian intestine is a prototype of a self-renewing organ. The rapid cellular turnover is supported by proliferating progenitors located in the intestinal crypt, which is also the stem cell location. Homeostasis of the intestinal epithelium has to be ...

EPFL2011

Evolutionary plasticity of segmentation clock networks

Andrew Charles Oates

The vertebral column is a conserved anatomical structure that defines the vertebrate phylum. The periodic or segmental pattern of the vertebral column is established early in development when the vertebral precursors, the somites, are rhythmically produced ...

2011

Identification and Preclinical Validation of Novel Inhibitors of the Notch Pathway

Rajwinder Lehal

Notch signaling is among one of the highly conserved developmental pathways. Because of its role in the regulation of stem cell self-renewal and cell fate decisions, Notch signaling maintains tissue homeostasis in several organs such as thymus, skin and in ...

EPFL2011

Dynamic fragmentation of ceramics, signature of defects and scaling of fragment sizes

Jean-François Molinari, Sarah Levy

Defects play a critical role in the dynamic fragmentation process of structural ceramics. Cracks initiate at seemingly random locations, propagate and coalesce to form fragments. The process is accompanied by stress release waves, whose influence is diffic ...

Elsevier2010