Publication
Plasmonic nanohole array biosensor for label-free and real-time analysis of live cell secretion
Publications associées (38)
Label-free plasmonic microarray for multiplexed analysis of cells and tumor organoids
Investigating the dynamic activities of protein expression and signaling in living organisms is a crucial focus of intense research aimed at elucidating the processes that underlie disease progression and improving treatments and drug development. Resolvin ...
EPFL2023Passive and Deterministic Droplet Microfluidics for Single Object Encapsulation and Pairing
The single-cell study, which dissects cell-cell heterogeneity from bulk populations, is of growing attention and importance in biological studies and clinical practices. At the core of the single-cell analysis is the efficient cell isolation and constructi ...
EPFL2023Single-Cell Optical Nanomotion of Candida albicans in Microwells for Rapid Antifungal Susceptibility Testing
Sandor Kasas, María Inés Villalba
Candida albicans is an emerging multidrug-resistant opportunistic pathogen representing an important source of invasive disease in humans and generating high healthcare costs worldwide. The development of a rapid and simple antifungal susceptibility test ( ...
MDPI2023Microfluidic T Cell Selection by Cellular Avidity
Li Tang, Armand Kurum, Alexandre Harari
No T cell receptor (TCR) T cell therapies have obtained clinical approval. The lack of strategies capable of selecting and recovering potent T cell candidates may be a contributor to this. Existing protocols for selecting TCR T cell clones for cell therapi ...
WILEY2022Real-time monitoring of single-cell secretion with a high-throughput nanoplasmonic microarray
Hatice Altug, Xiaokang Li, Yen-Cheng Liu, Saeid Ansaryan, Eduardo Romero Arvelo
Proteins secreted by cells play significant roles in mediating many physiological, developmental, and pathological processes due to their functions in intra/intercellular communication and signaling. Conventional end-point methods are insufficient for unde ...
2022An integrated microfluidic device for stem cell differentiation based on cell-imprinted substrate designed for cartilage regeneration in a rabbit model
Philippe Renaud, Mojtaba Taghipoor, Shahin Bonakdar, Leila Montazeri
Separating cells from the body and cultivating them in vitro will alter the function of cells. Therefore, for optimal cell culture in the laboratory, conditions similar to those of their natural growth should be provided. In previous studies, it has been s ...
2021Quantum Sensing of Free Radicals in Primary Human Dendritic Cells
Free radicals are crucial indicators for stress and appear in all kinds of pathogenic conditions, including cancer, cardiovascular diseases, and infection. However, they are difficult to detect due to their reactivity and low abundance. We use relaxometry ...
AMER CHEMICAL SOC2021Microfluidic devices for the study of cell-cell, cell-particle and particle-particle interactions
Margaux Catherine Marie Duchamp
Microfluidics and microtechnologies are of great interest for biological applications. This interest is linked to the fact that microtechnologies enable the study of single cells at the cellular and sub-cellular level. One of many applications of such sing ...
EPFL2020Label-free plasmonic biosensors for real-time live cell analysis
For decades, the understanding of life has been focused on its most fundamental building blocks: molecules. Deciphering the dynamic activities of protein molecules in human cells is of vital significance for fundamental and clinical studies. The minuscule ...
EPFL2019On‐chip technology for single‐cell arraying, electrorotation‐based analysis and selective release
Carlotta Guiducci, Samuel Kilchenmann, Kevin Keim, Paul Karoly Otto Ery, Mohamed Zakarya Alsaid Ali Rashed
This paper reports a method for label-free single-cell biophysical analysis of multiple cells trapped in suspension by electrokinetic forces. Tri-dimensional pillar electrodes arranged along the width of a microfluidic chamber define actuators for single c ...
2019