Publication
Enhancers of notch signaling and their use in the treatment of cancers and malignancies medicable by upregulation of notch
Publications associées (40)
Non-genomic activation of the AKT-mTOR pathway by the mitochondrial stress response in thyroid cancer
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Cancer progression is associated with metabolic reprogramming and causes significant intracellular stress; however, the mechanisms that link cellular stress and growth signalling are not fully understood. Here, we identified a mechanism that couples the mi ...
SPRINGERNATURE2022Optimization of the Distance between Cylindrical Light Distributors Used for Interstitial Light Delivery in Biological Tissues
Georges Wagnières, Aurelien Stephen Arnaud Gregor
Cylindrical light diffusers (CLDs) are often employed for the treatment of large tumors by interstitial photodynamic therapy (iPDT) and photoimmunotherapy (PIT), which involves careful treatment planning to maximize therapeutic dose coverage while minimizi ...
MDPI2022NovelT2Mapping for Evaluating Cervical Cancer Features by Providing QuantitativeT2Maps and Synthetic Morphologic Images: A Preliminary Study
Tobias Kober, Tom Hilbert, Yong Zhang, Meng Yang, Jie Liu
Background The application value of T(2)mapping in evaluating cervical cancer (CC) features remains unclear. Purpose To investigate the role of T(2)values in evaluating CC classification, grade, and lymphovascular space invasion (LVSI) in comparison to app ...
WILEY2020Prediction of Occult Lymph Node Metastasis in Head and Neck Cancer with CD31 Vessel Quantification
Objective The management of occult lymph node metastasis (LNM) in head and neck squamous cell carcinoma has been a matter of controversy for decades. The vascular density within the tumor microenvironment, as an indicator of ongoing angiogenesis, could con ...
SAGE PUBLICATIONS LTD2019CSL controls telomere maintenance and genome stability in human dermal fibroblasts
Joachim Lingner, Thomas Frédéric Lunardi, Paris Jafari
Genomic instability is a hallmark of cancer. Whether it also occurs in Cancer Associated Fibroblasts (CAFs) remains to be carefully investigated. Loss of CSL/RBP-J kappa, the effector of canonical NOTCH signaling with intrinsic transcription repressive fun ...
Springer2019Cancer cell-derived long pentraxin 3 (PTX3) promotes melanoma migration through a toll-like receptor 4 (TLR4)/NF-kappa B signaling pathway
Cutaneous melanoma is one of the most aggressive cancers characterized by a high plasticity, a propensity for metastasis, and drug resistance. Melanomas are composed of phenotypically diverse subpopulations of tumor cells with heterogeneous molecular profi ...
2019Nanoparticle Conjugation of Human Papillomavirus 16 E7-long Peptides Enhances Therapeutic Vaccine Efficacy against Solid Tumors in Mice
Douglas Hanahan, Mélanie Louise Tichet, Melody Swartz, Stephan Wullschleger, Gabriele Galliverti, Sylvie Hauert
Treatment of patients bearing human papillomavirus (HPV)-related cancers with synthetic long-peptide (SLP) therapeutic vaccines has shown promising results in clinical trials against premalignant lesions, whereas responses against later stage carcinomas ha ...
AMER ASSOC CANCER RESEARCH2018Advancing immunotherapy for HPV-related cancers: Improving therapeutic vaccination approaches and understanding the immunosuppressive role of myeloid cells
Human Papilloma Viruses (HPVs) are the most common sexually transmitted agents worldwide, and chronic infection with oncogenic HPVs can lead to the development of lesions in the cervix, the vulva, and the head and neck region. In some patients, these lesio ...
EPFL2018Novel compartment-specific biosensors reveal a complementary subcellular distribution of bioactive Furin and PC7
Proprotein Convertases (PCs) constitute a family of serine proteases that activate various
hormones, growth factors and cell adhesion molecules by mediating endoproteolytic cleavage
of their secreted inactive precursors during their transit in the secret ...
EPFL2018Correlation between podoplanin expression and extracapsular spread in squamous cell carcinoma of the oral cavity using subjective immunoreactivity scores and semiquantitative image analysis
Background. The correlation between podoplanin expression and extracapsular spread in head and neck squamous cell carcinoma (HNSCC) has never been reported. The purpose of this study was to assess the predictive value of podoplanin expression for this para ...
Wiley-Blackwell2017