Publication
Control of growth and gut maturation by &ITHoxD&IT genes and the associated lncRNA &ITHaglr&IT
Publications associées (35)
Analysis of Polycerate Mutants Reveals the Evolutionary Co-option of HOXD1 for Horn Patterning in Bovidae
Denis Duboule, Jozsef Zakany, Aurélie Hintermann
In the course of evolution, pecorans (i.e., higher ruminants) developed a remarkable diversity of osseous cranial appendages, collectively referred to as "headgear," which likely share the same origin and genetic basis. However, the nature and function of ...
OXFORD UNIV PRESS2021Compositions and methods for delivering nucleic acids to cochlear and vestibular cells
Bernard Schneider, Paola Andrea Solanes Vega
Provided herein are materials and methods for efficiently delivering nucleic acids to cochlear and vestibular cells, and methods of treating sensory transduction disorders associated with a genetic defect. ...
2019Coordinated Hoxd genes expression during embryogenesis is dependent on a strict disposition of genes and polarized regulators within the HoxD cluster
HOX transcription factors determine the identity of body regions along the rostro-caudal axis during bilaterian embryogenesis. In vertebrates Hox genes distinctively lie organized in dense clusters, each typically composed of a dozen paralogous transcripti ...
EPFL2018Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells
Denis Duboule, Guillaume Andrey, Patrick Schorderet, Nayuta Yakushiji
During embryonic development, fields of progenitor cells form complex structures through dynamic interactions with external signaling molecules. How complex signaling inputs are integrated to yield appropriate gene expression responses is poorly understood ...
National Academy of Sciences2017Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci
Denis Duboule, Marion Leleu, Daniël Noordermeer, Patrick Schorderet
Hox genes are essential regulators of embryonic development. Their step-wise transcriptional activation follows their genomic topology and the various states of activation are subsequently memorized into domains of progressively overlapping gene products. ...
Elife Sciences Publications Ltd2014Chromatin organization and global regulation of Hox gene clusters
During development, a properly coordinated expression of Hox genes, within their different genomic clusters is critical for patterning the body plans of many animals with a bilateral symmetry. The fascinating correspondence between the topological organiza ...
Royal Soc2013Multiple Enhancers Regulate Hoxd Genes and the Hotdog LncRNA during Cecum Budding
Denis Duboule, Marion Leleu, Saskia Joëlle Delpretti Anex
Hox genes are required for the development of the intestinal cecum, a major organ of plant-eating species. We have analyzed the transcriptional regulation of Hoxd genes in cecal buds and show that they are controlled by a series of enhancers located in a g ...
Elsevier2013A function for all posterior Hoxd genes during digit development?
Denis Duboule, Saskia Joëlle Delpretti Anex, Jozsef Zakany
Background: Four posterior Hoxd genes, from Hoxd13 to Hoxd10, are collectively regulated during the development of tetrapod digits. Besides the well-documented role of Hoxd13, the function of the neighboring genes has been difficult to evaluate due to the ...
2012A regulatory archipelago controls hox genes transcription in digits
The evolution of digits was an essential step in the success of tetrapods. Among the key players, Hoxd genes are coordinately regulated in developing digits, where they help organize growth and patterns. We identified the distal regulatory sites associated ...
2011A regulatory ‘landscape effect’ over the Hoxd cluster
Faithful expression of Hox genes in both time and space is essential for proper patterning of the primary body axis. Transgenic approaches in vertebrates have suggested that this collinear activation process is regulated in a largely gene cluster-autonomou ...
Elsevier2011