Fatigue as the missing link between bone fragility and fracture
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To comprehend the most detrimental characteristics behind bone fractures, it is key to understand the material and tissue level strain limits and their relation to failure sites. The aim of this study was to investigate the three-dimensional strain distrib ...
A mechanistic understanding of bone fracture is indispensable for developing improved fracture risk assessment in clinics. Since bone is a hierarchically structured material, gaining such knowledge requires analysis at multiple length scales. Here, the ten ...
BACKGROUND: Fracture fixation in weak bone is still a clinical challenge. Screw augmentation was shown to successfully increase their primary stability. The currently used calcium phosphate or polymeric bone cements, however, present important drawbacks su ...
Bone mass is maintained by osteoclasts that resorb bone and osteoblasts that promote matrix deposition and mineralization. Bone homeostasis is altered in chronic inflammation as well as in post-menopausal loss of estrogen, which favors osteoclast activity ...
Osteoporosis is a major health problem in our aging society. This metabolic disease, which is characterized by a deterioration of the bone microarchitecture and a significant loss of bone mass, is affecting a rising number of mostly elderly patients. The m ...
Osteogenesis imperfecta is an inherited connective tissue disorder with wide phenotypic and molecular heterogen- eity. A common issue associated with the molecular ab- normality is a disturbance in bone matrix synthesis and homeostasis inducing bone fragil ...
Swiss Medical Publishers Ltd / EMH Swiss Medical Publishers2016
Reversed shoulder arthroplasty (RSA) is recommended in case of severe muscle deficiency, along with important joint wear. Although having a correct placement of the prosthesis after the operation and a recovery of the mobility, several cases of scapula fra ...
The role of tissue-level post-yield behavior on the apparent-level strength of trabecular bone is a potentially important aspect of bone quality. To gain insight into this issue, we compared the apparent-level strength of trabecular bone for the hypothetic ...
Reverse total shoulder arthroplasty (rTSA) is recommended in case of severe muscle deficiency, along with important joint wear. Although having a correct placement of the prosthesis after the operation and a recovery of the mobility, several cases of scapu ...
Bone resorption is seminal for the physiological remodeling of bone during life. However, this process needs to be strictly controlled; excessive bone resorption results in pathologic bone loss, osteoporosis, and fracture. We describe a control mechanism o ...
