Chaperones convert the energy from ATP into the nonequilibrium stabilization of native proteins
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Protein folding stands as one of the major interdisciplinary challenges of the last ten years, involving biology, chemistry, medicine and physics. In this PhD thesis, we investigate the solvent effects and the resulting hydrophobic effect on proteins. In p ...
Although alcohols are well-known to be protein denaturants when present at high concentrations, their effect on proteins at low concentrations is much less well characterized. In this paper, we present a study of the effects of alcohols on protein stabilit ...
A detailed characterization of the time scales and mechanisms by which RNA molecules change their folding structure upon binding of metabolites or during catalysis is important for the understanding of the different biological functions of RNA. The folding ...
The fundamental aspects of classical thermodynamics are presented in a simple compact way. The equations derived are illustrated by numerous (111) examples, often direct application of the relations just obtained. The (four) laws of thermodynamics are pres ...
The fundamental aspects of classical thermodynamics are presented in a simple compact way. The equations derived are illustrated by numerous (111) examples, often direct application of the relations just obtained. The (four) laws of thermodynamics are pres ...
Hsp70 is a central molecular chaperone that passively prevents protein aggregation and uses the energy of ATP hydrolysis to solubilize, translocate, and mediate the proper refolding of proteins in the cell. Yet, the molecular mechanism by which the active ...
American Society for Biochemistry and Molecular Biology2004
The Bases of Chemical Thermodynamics: Volume 1 In this volume (volume 1), the fundamental aspects of thermodynamics are presented. The first and second laws of thermodynamics are illustrated. The need to define thermodynamic temperature and the nature of e ...
Quantum physics is the backbone of modem science: therefore, a correct first step is essential for students' success in many different disciplines. Unfortunately, many didactic approaches are still complicated, potentially confusing and often historically ...
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