Preservation of visual function in an animal model of retinal degeneration using CRISPR/Cas9 gene editing
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The discovery of a novel non-rod, non-cone photoreceptor in the mammalian eye that mediates a range of ‘non-visual’ responses to light has required reexamination of how lighting needs for human health are characterized and evaluated. Existing literature pr ...
Encoding of visual information in the brain is retinotopic: Neighboring points in the visual field are mapped onto neighboring photoreceptors in the retina, and these neighborhood relations are maintained in the early stages of cortical processing. However ...
There are uncertainties in the current daylight glare prediction models as they do not accurately predict the glare sensation that people experience. The objective of this research project is to investigate daylight glare stemming from contrast between tas ...
PurposeTo evaluate the relationship between the peripapillary metabolic alterations [retinal vessel Oximetry (RO)] and the structural findings [retinal vessel diameter and retinal nerve fibre layer thickness (RNFL)] in patients with inherited retinal dystr ...
Natural resources such as daylight and sunlight are highly appreciated in countries with prevailing overcast skies. Taking advantage of this scarce resource contributes to saving energy on artificial lighting. In contrast to northern, southern European cit ...
Hereditary retinal degenerations encompass a group of genetic diseases characterized by extreme clinical variability. Following next-generation sequencing and autozygome-based screening of patients presenting with a peculiar, recessive form of cone-dominat ...
This thesis introduces a new approach to characterize and evaluate ocular light exposure based on the discovery of novel blue light-sensitive photoreceptors in the human eye. These photoreceptors are the primary mediators of 'non-visual' responses impactin ...
Background: Leber congenital amaurosis is an early-onset childhood severe retinal dystrophy, of significant genetic heterogeneity. RPGRIP1 is ubiquitously expressed, but mutations in RPGRIP1 lead to a retina-restricted phenotype, such as Leber congenital a ...
The development of visual functions is very diverse. Some visual functions mature within the first year of life, whereas maturation for other functions extends into adolescence. The reasons for these developmental differences are largely unknown. Here, we ...
Unlike in cognition, audition and somatosensation, performance between various visual tasks does not correlate. Surprisingly, even tasks that appear similar, like visual acuity and line bisection task do not share much common variance. Similar results were ...
