Preservation of visual function in an animal model of retinal degeneration using CRISPR/Cas9 gene editing
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The vertebrate retina is a model system of the development of the central nervous system. Because of its rapid development and the availability of many molecular tools the zebrafish is an established model of retinal development. Development and maintenanc ...
The retina is one of the best known quantum detectors with rods able to reliably respond to single photons. However, estimates on the number of photons eliciting conscious perception, based on signal detection theory, are systematically above these values ...
Purpose: To study the influence of retinal structural changes on oxygen saturation in retinitis pigmentosa (RP) patients. Methods: Oximetry measurements were performed on 21 eyes of 11 RP patients and compared to 24 eyes of 12 controls. Retinal oxygen satu ...
Sight restoration is one of the new frontiers for prosthetic devices that enable the electrical stimulation of neurons. In particular, diseases that affect the retinal pigment epithelium and photoreceptors but preserve the inner retinal layers are preferen ...
The major active retinoid, all-trans retinoic acid, has long been recognized as critical for the development of several organs, including the eye. Mutations in STRA6, the gene encoding the cellular receptor for vitamin A, in patients with MatthewWood syndr ...
The goal of this thesis is to develop a computer-based lighting simulation framework capable of predicting human non-visual responses to light and to validate novel guidelines that can inform designers about how lighting might affect human non-visual respo ...
We propose a head pose invariant gaze estimation model for distant RGB-D cameras. It relies on a geometric understanding of the 3D gaze action and generation of eye images. By introducing a semantic segmentation of the eye region within a generative proces ...
Purpose: Retinitis pigmentosa (RP; MIM 268000) is a hereditary disease characterized by poor night vision and progressive loss of photoreceptors, eventually leading to blindness. This degenerative process primarily affects peripheral vision due to the loss ...
The discovery of a novel non-rod, non-cone photoreceptor in the human eye that mediates a number of effects on the brain has sparked a growing interest in incorporating these non-visual effects of light into the design process of buildings. Appropriately–t ...
This paper describes a climate-based simulation framework devised to investigate the potential for the non-visual effects of daylight in buildings. It is part 2 of a study where the first paper focused on the formulation of the photobiological underpinning ...
