Publication

Brain metabolism during Chronic Hepatic Encephalopathy studied by in vivo 1H and 31P MRS

Publications associées (91)

New insights into rodent brain microstructure and metabolism in hepatic encephalopathy

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Type C hepatic encephalopathy (HE) is a severe neuropsychiatric complication of chronic liver disease, for which the prognosis is poor in the absence of liver transplantation. Cirrhosis in type C HE leads to a toxic accumulation of ammonia in the blood, wh ...
EPFL2023

Robust gamma-aminobutyric acid and energy metabolism measurements by proton and phosphorus magnetic resonance spectroscopy and fingerprinting

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Magnetic resonance spectroscopy (MRS) is the only technique that can detect endogenous metabolites directly and non-invasively in vivo. It allows to identify different metabolites and analyze the dynamic neurochemical processes in the brain, skeletal muscl ...
EPFL2023

Lessons on brain edema in HE: from cellular to animal models and clinical studies

Cristina Ramona Cudalbu, Katarzyna Pierzchala, Jessie Julie Mosso

Brain edema is considered as a common feature associated with hepatic encephalopathy (HE). However, its central role as cause or consequence of HE and its implication in the development of the neurological alterations linked to HE are still under debate. I ...
SPRINGER/PLENUM PUBLISHERS2023

Enabling Stroke Theranostics with Hyperpolarized Magnetic Resonance

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The severe social and economic burden of stroke is a strong motivation for the exploration of innovative medical approaches. In this context, magnetic resonance (MR) of hyperpolarized (HP) molecular agents via dissolution dynamic nuclear polarization (dDNP ...
EPFL2023

Spatiotemporal Metabolic Liver Zonation and Consequences on Pathophysiology

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Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis. Division of labor between hepatocytes is critical to coordinate complex comp ...
ANNUAL REVIEWS2023

Neurometabolic profiles of bile duct ligated rats after the treatment with an urease inhibitor – 1H MRS dataset

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1H MRS in the cerebellum was used to study the effect of 2-octynohydroxamic acid (2-octynoHA) treatment on the brain of bile duct ligated (BDL) rats (type C hepatic encephalopathy). The study included four groups of rats: negative control group (rats recei ...
Zenodo2023

Advanced metabolite mapping at ultra-high field using 1H-MRS, 1H-MRSI and macromolecules: applications in a rat model of type C hepatic encephalopathy

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Magnetic Resonance Spectroscopy (MRS) is the only technique capable of measuring a large number of metabolites simultaneously in vivo. Ultra-high magnetic fields (UHF) combined with ultra-short echo time (TE) sequences allow the detection of high-quality 1 ...
EPFL2022

Dissecting the role of biliary epithelial cells during non-alcoholic fatty liver disease progression

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The liver is the largest solid organ and the only one capable of using regenerative mechanisms to recover its mass fully. Although liver regeneration from acute injuries has been effective and extensively studied, chronic liver damage has adverse effects o ...
EPFL2022

Overview of oxidative stress findings in hepatic encephalopathy: From cellular and ammonium-based animal models to human data

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Oxidative stress is a natural phenomenon in the body. Under physiological conditions intracellular reactive oxygen species (ROS) are normal components of signal transduction cascades, and their levels are maintained by a complex antioxidants systems partic ...
ACADEMIC PRESS INC ELSEVIER SCIENCE2022

Dissecting the role of the asparagine synthesis in acute liver injury

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Amino acids are some of the main building stones of life used in a variety of biological processes, such as protein synthesis, energy metabolism or even as precursors for hormone synthesis. How-ever, some of them also participate and coordinate certain cel ...
EPFL2022

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