Publication

Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury

Publications associées (38)

Neuromodulation/neurostimulation system for mitigating locomotor deficits of parkinson's disease, spinal cord injury (sci), stroke and/or other neurological disorders

Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Jordan Squair, Léonie Asboth, Tomislav Milekovic, Robin Jonathan Demesmaeker

The present invention relates to a combined neuromodulation and/or neurostimulation system (10) for mitigating locomotor deficits of/or neuronal disorders, especially Parkinson's disease, said system (10) comprising: - at least one Deep Brain Stimulation ( ...

2023

Brain-controlled spinal cord stimulation to restore mobility after spinal cord injury.

Carmina Andrea Galvez Solano

Spinal Cord Injury (SCI) affects almost 500,000 people every year, causing complete paralysis of both legs in severe cases, with no current treatment perspective. However, new neuroengineering technologies, such as the Brain Spine Interface (BSI), have eme ...

EPFL2023

Walking naturally after spinal cord injury using a brain-spine interface

Grégoire Courtine, Jocelyne Bloch, Léonie Asboth, Robin Jonathan Demesmaeker, Anne Marie Lucienne Watrin, Sergio Daniel Hernandez, Henri Charles Alexandre Lorach, Jimmy James Ravier, Grégory Didier Dumont, Félix Antoine Martel, Laure Coquoz, Valeria Spagnolo, Thibault Jean Etienne Collin, Icare Sakr, Lucas Struber, Salif Axel Komi, Molywan Vat, Carmina Andrea Galvez Solano, Edeny Baaklini, Cathal John Harte

A spinal cord injury interrupts the communication between the brain and the region of the spinal cord that produces walking, leading to paralysis(1,2). Here, we restored this communication with a digital bridge between the brain and spinal cord that enable ...

NATURE PORTFOLIO2023

Longitudinal interrogation of sympathetic neural circuits and hemodynamics in preclinical models

Grégoire Courtine, Quentin Barraud, Jordan Squair, Matthieu Pierre Gautier, Rémi Bernard René Hudelle, Suje Amir, Victor Perez Puchalt, Loïs Thomas Romain Mahe, Jan Elaine Cuevas Soriano

Neurological disorders, including spinal cord injury, result in hemodynamic instability due to the disruption of supraspinal projections to the sympathetic circuits located in the spinal cord. We recently developed a preclinical model that allows the ident ...

NATURE PORTFOLIO2022

Personalizable computational models of electrical spinal cord stimulation to restore function after neurological disorders

Andreas Rowald

Spinal Cord Injury (SCI) disrupts the communication between the brain and spinal circuits below the lesion, leading to a plethora of neurological impairments, including the loss of motor function. At present, the only medical practices to enhance recovery ...

EPFL2021

Electrical spinal cord stimulation protocols to regulate motor and autonomic functions in people with neurological disorders

Robin Jonathan Demesmaeker

Neurological disorders such as spinal cord injury (SCI) massively reduce independence and quality of life. Most often, the majority of the nervous system is still fully or partially spared, but dysfunctional due to aberrant or absent descending input from ...

EPFL2021

Development of a peripheral neuroprosthesis to elicit fine hand movements in primates

Marion Aimée Geneviève Badi-Dubois

Neurological disorders such as spinal cord lesion and stroke disturb sensorimotor pathways and result in severe motor deficits that can dreadfully impact the quality of life of affected individuals. Strategies aiming at restoring hand function after upper- ...

EPFL2021

A Review of Microelectronic Systems and Circuit Techniques for Electrical Neural Recording Aimed at Closed-Loop Epilepsy Control

Alexandre Schmid, Reza Ranjandish

Closed-loop implantable electronics offer a new trend in therapeutic systems aimed at controlling some neurological diseases such as epilepsy. Seizures are detected and electrical stimulation applied to the brain or groups of nerves. To this aim, the signa ...

2020

The relevance of the artery of Adamkiewicz for microsurgical resection of spinal tumors- short overview and case series: Technical note

Introduction. - There is of major interest to know the exact anatomical location of artery of Adamkiewicz (AKA) for many spinal microsurgical procedures, so as to avoid postoperative ischemia of the spinal cord, with further devastating clinical impact. Me ...

2020

Spatiotemporal stimulation strategies in neuroprostheses to improve locomotion after spinal cord injury

Jérôme Gandar

Spinal cord injury (SCI) disrupts communication within central nervous system and lead to range of neurological disorders including paralysis. Current rehabilitation strategies to restore locomotion are poorly effective in people with severe SCI. Epidural ...

EPFL2019

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