Publication

Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

Publications associées (36)

Axon regeneration and circuit reorganization after complete spinal cord injury

First human trials involving neuroprosthetic rehabilitation demonstrated recently that significant functional benefits can be achieved with lumbosacral neuromodulation and reorganized spared projections. However, complete spinal cord injuries (SCI) wholly ...

EPFL2019

Prefrontal-Premotor Pathways and Motor Output in Well-Recovered Stroke Patients

Friedhelm Christoph Hummel

Structural brain imaging has continuously furthered our knowledge how different pathways of the human motor system contribute to residual motor output in stroke patients. Tract-related microstructure of pathways between primary and premotor areas has been ...

2019

Reverse engineering the motor control system

Berat Denizdurduran

Mammalian motor control is implemented by a combination of different networks and system, working coherently to plan the movement of the body or a limb and to execute this movement a dynamical environment. While it is believed that complex, voluntary movem ...

EPFL2019

Dopaminergic modulation of cortical motor network lateralization

Michael Herzog, Bogdan Draganski, Maya Anna Jastrzebowska, Lester Melie Garcia, Renaud Marquis

Introduction Unilateral movements are primarily processed in contralateral cortical and subcortical areas and additionally in ipsilateral cerebellum, leading to an asymmetric pattern of neural activation. Decrease of lateralization is characteristic of agi ...

2018

Brain-controlled neuroprosthetic interventions to restore locomotion after contusion spinal cord injury in the rat

Marco Bonizzato

Spinal cord injury (SCI), second only to stroke, is the leading cause of paralysis. Therapies based on electrical stimulation of the spinal cord and other locomotor areas of the Nervous System improve motor control in people with neurotrauma. Neuromodulati ...

EPFL2017

Cortico-reticulo-spinal circuits mediate functional recovery after spinal cord contusion

Léonie Asboth

After a spinal cord injury (SCI), only half of affected individuals regain voluntary control of leg movements below the level of the lesion. Anatomical, electrophysiological and imaging data revealed that even the most severe forms of SCI usually spare a s ...

EPFL2017

Interactions between the corticospinal tract and premotor-motor pathways in stroke recovery

Friedhelm Christoph Hummel

Background and Purpose-Brain imaging has continuously enhanced our understanding how different brain networks contribute to motor recovery after stroke. However, the present models are still incomplete and do not fit for every patient. The interaction betw ...

American Heart Association2017

Brain-Controlled Neuroprosthetic Therapies And Mechanisms Of Recovery After Spinal Cord Injury

Galyna Pidpruzhnykova

Spinal cord injury (SCI) is the second leading cause of paralysis, which induces abrupt impairments with devastating consequences for the quality of life of patients. Despite significant progress in SCI treatment through neurorehabilitation training and sp ...

EPFL2017

A brain-spine interface alleviating gait deficits after spinal cord injury in primates

Silvestro Micera, Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Quentin Barraud, Tomislav Milekovic, Marco Capogrosso, Fabien Bertrand Paul Wagner, Jérôme Gandar, Jean-Baptiste Mignardot, David Allenson Borton, Simone Ellen Joze Duis, Elodie Rey

Spinal cord injury disrupts the communication between the brain and the spinal circuits that orchestrate movement. To bypass the lesion, brain-computer interfaces(1-3) have directly linked cortical activity to electrical stimulation of muscles, and have th ...

Nature Publishing Group2016

Distinct vestibular effects on early and late somatosensory cortical processing in humans

Olaf Blanke, Fosco Bernasconi, Michiel van Elk, Christian Pfeiffer

In non-human primates several brain areas contain neurons that respond to both vestibular and somatosensory stimulation. In humans, vestibular stimulation activates several somatosensory brain regions and improves tactile perception. However, less is known ...

Academic Press Inc Elsevier Science2016

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