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Composite Double-Network Hydrogels To Improve Adhesion on Biological Surfaces

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Nowadays, the development of cell therapy relies mainly on the advances made toward cell microencapsulation which allows to evade the need for immunosuppression during cell transplantation. Among the materials considered for cell encapsulation, hydrogels d ...

EPFL2018

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The production of hydrogel microspheres (MS) for cell immobilization, maintaining the favorable properties of alginate gels but presenting enhanced performance in terms of in vivo durability and physical properties, is desirable to extend the therapeutic p ...

Amer Chemical Soc2017

Decellularization of bovine articular cartilage by supercritical carbon dioxide as a matrix for cartilage repair

Giulia Weissenberger

Decellularized extracellular matrix (ECM) derived scaﬀolds serve as potential candidates in the application of cartilage regeneration to guide cells into proliferating and maintaining the structural zones of articular cartilage. ECM tissue matrices oﬀer fr ...

2017

Nano Fibrillated Cellulose Based Composite Hydrogels for an Injectable Intervertebral Disc Implant

Azadeh Khoushabi

Replacing the gel-like central part of the intervertebral disc (IVD), so-called nucleus pulposus (NP), via a minimally invasive surgery is one of the most recent approaches in the lower back pain treatments. An appropriate biomaterial for NP replacement (N ...

EPFL2016

Biodegradable HEMA-based hydrogels with enhanced mechanical properties

Dominique Pioletti, Mohamadreza Nassajian Moghadam

Hydrogels are widely used in the biomedical field. Their main purposes are either to deliver biological active agents or to temporarily fill a defect until they degrade and are followed by new host tissue formation. However for this latter application, bio ...

Wiley-Blackwell2016

In this study we present a photocrosslinkable and layerable hydrogel based on decellularized extracellular matrix (dECM) intended for in vitromodels of cartilage tissue formation. dECM can provide cellular environments that are close to the native tissue s ...

2016

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The application of hydrogels as load-bearing biomedical components is often limited by their mechanical properties. Often an attempt to improve a hydrogel's stiffness is accompanied by a loss of toughness and swelling properties. In this work, we show that ...

Elsevier Sci Ltd2015

Strategies for improving the repair of focal cartilage defects

Dominique Pioletti, Philippe Abdel Sayed

Articular cartilage, together with skin, was predicted to be one of the first tissues to be successfully engineered. However cartilage repair remains nowadays still elusive, as we are still not able to overcome the hurdles of creating biomaterials correspo ...

Future Medicine Ltd2015

Crystalline Oligo(ethylene sulfide) Domains Define Highly Stable Supramolecular Block Copolymer Assemblies

Davide Demurtas, Jeffrey Alan Hubbell, Edward Allen Phelps, Carrie Ellen Brubaker

With proper control over copolymer design and solvation conditions, self-assembled materials display impressive morphological variety that encompasses nanoscale colloids as well as bulk three-dimensional architectures. Here we take advantage of both hydrop ...

Amer Chemical Soc2015

Improving hydrogels’ toughness by increasing the dissipative properties of their network

Dominique Pioletti, Mohamadreza Nassajian Moghadam

The weak mechanical performance and fragility of hydrogels limit their application as biomaterials for load bearing applications. The origin of this weakness has been explained by the low resistance to chains breakage composing the hydrogel and to the crac ...

Elsevier2015