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A model for cellular mechanotransduction and contractility at finite strain

Publications associées (48)

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Application des réseaux de Bragg à la détermination des déformations distribuées dans les matériaux composites

The behaviour of brittle matrix fibre reinforced-composites is dependent of the properties of its constituents (fibre, matrix and fibre-matrix interface) and is affected by the mechanical and environmental loads. The fracture of a unidirectional composite ...

EPFL2009

Role of focal adhesions and mechanical stresses in the formation and progression of the lamellum interface

Actin network in the front part of a moving cell is organized into a lamellipodium and a lamellum. A distinct lamellipodium-lamellum interface is associated with focal adhesions and consists of a series of arclike segments linking neighboring focal adhesio ...

2009

Arterial biomechanics after destruction of cytoskeleton by Cytochalasin D

Nikolaos Stergiopoulos, Sylvain Roy, Paolo Silacci, Tyler Nerton Thacher

Vascular smooth muscle is a major structural element of the arterial wall. We examined the effects of cytoskeleton destruction, after administration of Cytochalasin D, on the biomechanical properties of porcine common carotids. Compared to untreated, maxim ...

2009

The present research represents a theoretical and experimental contribution to the understanding of the structural behaviour of elements made of ultra-high performance fibre-reinforced concrete (UHPFRC). UHPFRC is investigated as an advanced cementitious m ...

EPFL2008

Miniaturized bioanalytics to probe the function of membrane proteins

Pedro Pascoal

G-protein coupled receptors (GPCRs) are the most abundant class of proteins in the cell body. Such receptors are of major interest as potential therapeutic targets. Downscaling and parallelization of bioanalytics opens novel routes to rapidly screen and id ...

EPFL2008

The response of embedded FBG sensors to non-uniform strains in CFRP composites during processing and delamination

Larissa Sorensen

From airplanes to sailboats to bridges, composite materials have become a significant part of our everyday structures. With increasing demand, these materials are pushed to their limits to improve structural efficiency. As a consequence, research and devel ...

EPFL2007

The role of the inflammasome in cellular responses to toxins and bacterial effectors

Françoise Gisou van der Goot Grunberg

Invading pathogens are recognized by mammalian cells through dedicated receptors found either at the cell surface or in the cytoplasm. These receptors, like the trans-membrane Toll-like Receptors (TLR) or the cytosolic Nod-like Receptors (NLR), initiate in ...

Springer-Verlag2007

Dynamics of actin and myosin II during cell polarization and directional locomotion

Sophie Bohnet

Crawling cell motility is characteristic of most animal cells and is involved in many important biological processes such as embryogenesis, immune response, and wound healing. It involves several steps: protrusion (dynamic surface extension) at the front o ...

EPFL2006

The purpose of this thesis is to characterize internal strains in polymeric materials due to consolidation. In view of this, optical Fiber Bragg Grating sensors are an excellent non-destructive tool for internal strain characterization and damage detection ...

EPFL2006

The N-terminal Ac-EEED sequence plays a role in alpha-smooth-muscle actin incorporation into stress fibers

Boris Hinz

We have previously shown that the N-terminal sequence AcEEED of alpha-smooth-muscle actin causes the loss of alpha-smooth-muscle actin from stress fibers and a decrease in cell contractility when introduced in myofibroblasts as a cell-penetrating fusion pe ...

Company of Biologists2005