Publication
Semisynthetic sensor proteins enable metabolic assays at the point of care
Publications associées (44)
Hemoglobin-stabilized gold nanoclusters displaying oxygen transport ability, self-antioxidation, auto-fluorescence properties and long-term storage potential
The development of hemoglobin (Hb)-based oxygen carriers (HBOCs) holds a lot of potential to overcome important drawbacks of donor blood such as a short shelf life or the potential risk of infection. However, a crucial limitation of current HBOCs is the au ...
ROYAL SOC CHEMISTRY2023Ultraflexible flow directed device and system
Mahmut Selman Sakar, Pietro Luciano Jakobus Dirix
A flow directed device adapted to be guided by a fuid, such as blood, flow within a tubular structure such as a blood vessel is disclosed, said device comprising a proximal end (100), a distal end (101) and an elongated body (102) in between defining a lon ...
2021Pharmacokinetics and biodistribution study of self-assembled Gd-micelles demonstrating blood-pool contrast enhancement for MRI
Lothar Helm, Yohan Van de Looij
Magnetic resonance angiography (MRA) requires the use of contrast agents (CAs) to enable accurate diagnosis. There are currently no CAs on the market with appropriate pharmacokinetic (PK) parameters, namely long persistence in the blood, that can be easily ...
2019A biosensor for measuring NAD(+) levels at the point of care
Johan Auwerx, Kai Johnsson, Luc Patiny, Elena Katsyuba, Qiuliyang Yu, Lin Xue
The cellular level of nicotinamide adenine dinucleotide (NAD(+)), through its different functions, affects cellular metabolism and signalling(1-3). A decrease in the NAD(+) content has been associated with various pathologies and physiological aging(4,5), ...
NATURE PUBLISHING GROUP2019Label-free Bacteria Quantification in Blood Plasma by a Bioprinted Microarray Based Interferometric Point-of-Care Device
Hatice Altug, Filiz Yesilköy, Alexander Belushkin
Existing clinical methods for bacteria detection lack speed, sensitivity, and, importantly, point-of-care (PoC) applicability. Thus, finding ways to push the sensitivity of clinical PoC biosensing technologies is crucial. Here we report a portable PoC devi ...
AMER CHEMICAL SOC2019Microdevice-integrated immunoassays for Point-of-Care Therapeutic Drug Monitoring
A significant number of drugs exhibit narrow therapeutic windows and high inter-individual pharmacokinetic variability. In such cases, Therapeutic Drug Monitoring (TDM) is compulsory in order to optimize the efficacy of the drug while avoiding adverse effe ...
EPFL2018Cofactor sensing proteins for metabolic assays at point-of-care
Miniaturized blood analysis promises a substantial improvement for the process of healthcare. However, most current blood analysis methods were developed in the context of centralized laboratories and there is a lack of robust detection technologies suitab ...
EPFL2018Vitamin B12 deficiency and impaired expression of amnionless during aging
Sonia Karaz, Laurence Goulet, Alice Pannerec
Background Physical frailty and loss of mobility in elderly individuals lead to reduced independence, quality of life, and increased mortality. Vitamin B12 deficiency has been linked to several age-related chronic diseases, including in the musculo-skeleta ...
2018Microdevice for Sedimentation-based Separation of Blood Microsamples at the Point of Collection
Laboratory blood testing plays a central role in current diagnostics and therapeutical decisions. Thus, errors have a direct impact on care quality and cost. The majority of errors occur in the pre-analytical phase, when samples are collected, stored and p ...
EPFL2017Protein Corona: Impact of Lymph Versus Blood in a Complex In Vitro Environment
Heinrich Hofmann, Duncan Thomas Lindsay Alexander, Diego Chiappe, Marc Moniatte, Ulrich Aschauer, Marijana Mionic Ebersold, Débora Bonvin
In biological environments, the surface of nanoparticles (NPs) are modified by protein corona (PC) that determines their biological behavior. Unfortunately, in vitro tests still give different PC than in vivo tests causing in vitro-in vivo discrepancy; hen ...
Wiley-Blackwell2017