Publications associées à De novo NAD(+) synthesis enhances mitochondrial function and improves health

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3

Nutrient availability is the major regulator of life and reproduction, and a complex cellular signaling network has evolved to adapt organisms to fasting. These sensor pathways monitor cellular energy metabolism, especially mitochondrial ATP production and ...

Wiley Open Access2014

Control of Mitochondrial pH by Uncoupling Protein 4 in Astrocytes Promotes Neuronal Survival

Pierre Magistretti, Hélène Danielle Perreten Lambert, Sylvain Eric Lengacher, Manuel Raphael Zenger, Jean-Yves Chatton

Brain activity is energetically costly and requires a steady and highly regulated flow of energy equivalents between neural cells. It is believed that a substantial share of cerebral glucose, the major source of energy of the brain, will preferentially be ...

American Society for Biochemistry and Molecular Biology2014

Mitonuclear protein imbalance as a conserved longevity mechanism

Johan Auwerx, Graham Knott, Laurent Mouchiroud, Richardus Houtkooper, Dongryeol Ryu, Elena Katsyuba, Norman Lionel Moullan

Longevity is regulated by a network of closely linked metabolic systems. We used a combination of mouse population genetics and RNA interference in Caenorhabditis elegans to identify mitochondrial ribosomal protein S5 (Mrps5) and other mitochondrial riboso ...

Nature Publishing Group2013

Mitochondrial sirtuins and metabolic homeostasis

Johan Auwerx, Eija Riitta Pirinen, Giuseppe Lo Sasso

The maintenance of metabolic homeostasis requires the well-orchestrated network of several pathways of glucose, lipid and amino acid metabolism. Mitochondria integrate these pathways and serve not only as the prime site of cellular energy harvesting but al ...

Elsevier Sci Ltd2012

CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability

Johan Auwerx, Carlos Canto Alvarez, Chikage Mataki, Hiroyasu Yamamoto, Lilia Noriega Lopez, Jiujiu Yu

The nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase SIRT1 is a major metabolic regulator activated by energy stresses such as fasting or calorie restriction. SIRT1 activation during fasting not only relies on the increase in the NAD(+)/NAD ...

2011

PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure

Johan Auwerx, Carlos Canto Alvarez, Hiroyasu Yamamoto

SIRT1 is a NAD+-dependent enzyme that affects metabolism by deacetylating key transcriptional regulators of energy expenditure. Here, we tested whether deletion of PARP-2, an alternative NAD+-consuming enzyme, impacts on NAD+ bioavailability and SIRT1 acti ...

Elsevier2011

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Richardus Houtkooper, Hiroyasu Yamamoto

SIRT1 regulates energy homeostasis by controlling the acetylation status and activity of a number of enzymes and transcriptional regulators. The fact that NAD(+) levels control SIRT1 activity confers a hypothetical basis for the design of new strategies to ...

Elsevier2011

Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility

Johan Auwerx, Kristina Schoonjans, Ellen Helena Jeninga

rganisms adapt their metabolism to meet ever changing environmental conditions. This metabolic adaptation involves at a cellular level the fine tuning of mitochondrial function, which is mainly under the control of the transcriptional co-activator prolifer ...

2010

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De novo NAD(+) synthesis enhances mitochondrial function and improves health

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3

Control of Mitochondrial pH by Uncoupling Protein 4 in Astrocytes Promotes Neuronal Survival

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING

Mitonuclear protein imbalance as a conserved longevity mechanism

Mitochondrial sirtuins and metabolic homeostasis

CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability

PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility

Protein deacetylation by SIRT1: An emerging key post- translational modification in metabolic regulation

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Chattez avec Graph Search

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3

Control of Mitochondrial pH by Uncoupling Protein 4 in Astrocytes Promotes Neuronal Survival

Mitochondrial sirtuins and metabolic homeostasis

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING

CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability

PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure

Protein deacetylation by SIRT1: An emerging key post- translational modification in metabolic regulation

Mitonuclear protein imbalance as a conserved longevity mechanism