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FIBCD1 Binds Aspergillus fumigatus and Regulates Lung Epithelial Response to Cell Wall Components

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Topology Repairing of Disconnected Pulmonary Airways and Vessels: Baselines and a Dataset

Jiancheng Yang

Accurate segmentation of pulmonary airways and vessels is crucial for the diagnosis and treatment of pulmonary diseases. However, current deep learning approaches suffer from disconnectivity issues that hinder their clinical usefulness. To address this cha ...

Cham2023

Multi-site, Multi-domain Airway Tree Modeling

Jiancheng Yang, Yi Wu, Ying Zhu, Boyu Zhang

Open international challenges are becoming the de facto standard for assessing computer vision and image analysis algorithms. In recent years, new methods have extended the reach of pulmonary airway segmentation that is closer to the limit of image resolut ...

Amsterdam2023

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Respiratory mucus lining the airway epithelium constitutes an important first line of defense against infection with influenza A virus (IAV). Previous studies suggested that the inhibitory potential of mucus relies not only on the presence of decoy recepto ...

2023

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Objectives Parametric response mapping (PRM) enables the evaluation of small airway disease (SAD) at the voxel level, but requires both inspiratory and expiratory chest CT scans. We hypothesize that deep learning PRM from inspiratory chest CT scans can eff ...

London2023

What Makes for Automatic Reconstruction of Pulmonary Segments

Jiancheng Yang, Li Zhang, Hongwei Li, Bo Du, Jingyu Li

3D reconstruction of pulmonary segments plays an important role in surgical treatment planning of lung cancer, which facilitates preservation of pulmonary function and helps ensure low recurrence rates. However, automatic reconstruction of pulmonary segmen ...

SPRINGER INTERNATIONAL PUBLISHING AG2022

Disparate temperature-dependent virus-host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium

Bart Deplancke, Bastien Mangeat, Vincent Roland Julien Gardeux, Julie Marie Russeil, Jörn Pezoldt, Elisa Cora, Daniel Alpern

Since its emergence in December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally and become a major public health burden. Despite its close phylogenetic relationship to SARS-CoV, SARS-CoV-2 exhibits increased human-to- ...

PUBLIC LIBRARY SCIENCE2021

Functional and structural characterization of Serratia marcescens ExbB: determinants of the interaction with HasB/TonB

Henning Paul-Julius Stahlberg

ExbBD is part of a cytoplasmic membrane molecular motor driven by the proton-motive force. It belongs to the larger family of motors involved in nutriment import across the outer membrane of Gram-negative bacteria (ExbBD), flagellar rotation (MotAB) or lat ...

2021

The ongoing pandemic of the coronavirus disease (Covid-19), caused by the spread of the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), highlights the need for broad-spectrum antiviral drugs. In this Essay, it is argued that such agents alrea ...

WILEY2021

Toxicity and translocation of Ag, CuO, ZnO and TiO2 nanoparticles upon exposure to fish intestinal epithelial cells

Kristin Schirmer, Laura Sigg

Understanding the ability of fish intestinal cells to act as a barrier for nanoparticle (NP) uptake and their effects is of significance from an environmental perspective as well as for human health, for which fish serves as an important nutrient source. W ...

ROYAL SOC CHEMISTRY2021

Characterization of Protein-Membrane Interfaces through a Synergistic Computational-Experimental Approach

Alessio Prunotto

The characterization of biological interfaces is widely recognized as one of the main challenges for modern biology. In particular, biological membranes are nowadays known to be an active environment that allows membrane proteins to perform their work and ...

EPFL2020