Publication
Visual masking deficits in schizophrenia: A view into the genetics of the disease through an endophenotype
Publications associées (45)
Associations of genetic and infectious risk factors with coronary heart disease
Jacques Fellay, Christian Axel Wandall Thorball, Zhi Ming Xu, Flavia Aurelia Shoko Hodel, Roxane De La Harpe
Coronary heart disease (CHD) is one of the most pressing health problems of our time and a major cause of preventable death. CHD results from complex interactions between genetic and environmental factors. Using multiplex serological testing for persistent ...
eLIFE SCIENCES PUBL LTD2023Using population-specific add-on polymorphisms to improve genotype imputation in underrepresented populations
Jacques Fellay, Zhi Ming Xu, Sina Rüeger
Genome-wide association studies rely on the statistical inference of untyped variants, called imputation, to increase the coverage of genotyping arrays. However, the results are often suboptimal in populations underrepresented in existing reference panels ...
San Francisco2022Secure and Federated Genome-Wide Association Studies for Biobank-Scale Datasets
Jean-Pierre Hubaux, Juan Ramón Troncoso-Pastoriza, Apostolos Pyrgelis, Jeffrey Chen, David Jules Froelicher
Sharing data across multiple institutions for genome-wide association studies (GWAS) would enable discovery of novel genetic variants linked to health and disease. However, existing regulations on genomic data sharing and the sheer size of the data limit t ...
2022The interplay between human genetic variation, chronic inflammation and persistent infection: relevance for cardiovascular morbidity
Contemporary genomic approaches allow us to seek answers to biological questions that were previously out of reach. Genome-wide association studies (GWAS) have identified numerous genetic polymorphisms associated with human diseases, providing new insight ...
EPFL2022A Phylogeny-aware GWAS Framework to Correct for Heritable Pathogen Effects on Infectious Disease Traits
Jacques Fellay, Christian Axel Wandall Thorball
Infectious diseases are particularly challenging for genome-wide association studies (GWAS) because genetic effects from two organisms (pathogen and host) can influence a trait. Traditional GWAS assume individual samples are independent observations. Howev ...
OXFORD UNIV PRESS2022Host Genomics of the HIV-1 Reservoir Size and Its Decay Rate During Suppressive Antiretroviral Treatment
Jacques Fellay, Christian Axel Wandall Thorball, Alessandro Borghesi
Background: The primary hurdle for the eradication of HIV-1 is the establishment of a latent viral reservoir early after primary infection. Here, we investigated the potential influence of human genetic variation on the HIV-1 reservoir size and its decay r ...
LIPPINCOTT WILLIAMS & WILKINS2020Genome-wide variation in nucleotides and retrotransposons in alpine populations of Arabis alpina (Brassicaceae)
Advances in high‐throughput sequencing have promoted the collection of reference genomes and genome‐wide diversity. However, the assessment of genomic variation among populations has hitherto mainly been surveyed through single‐nucleotide polymorphisms (SN ...
2019Large-scale variational inference for Bayesian joint regression modelling of high-dimensional genetic data
Genetic association studies have become increasingly important in understanding the molecular bases of complex human traits. The specific analysis of intermediate molecular traits, via quantitative trait locus (QTL) studies, has recently received much atte ...
EPFL2019Common genetic variants associated with Parkinson's disease display widespread signature of epigenetic plasticity
Giovanna Ambrosini, Philipp Bucher, Amit Sharma, Tikam Chand Dakal
Parkinson disease (PD) is characterized by a pivotal progressive loss of substantia nigra dopaminergic neurons and aggregation of alpha-synuclein protein encoded by the SNCA gene. Genome-wide association studies identified almost 100 sequence variants link ...
Springer2019Adaptation of hepatitis C virus to interferon lambda polymorphism across multiple viral genotypes
Jacques Fellay, Nimisha Chaturvedi
Genetic polymorphism in the interferon lambda (IFN-lambda) region is associated with spontaneous clearance of hepatitis C virus (HCV) infection and response to interferon-based treatment. Here, we evaluate associations between IFN-l polymorphism and HCV va ...
ELIFE SCIENCES PUBLICATIONS LTD2019