Population density and water balance influence the global occurrence of hepatitis E epidemics
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In a genome-wide association study of patients being treated for chronic hepatitis C, 2 functional variants in ITPA that cause inosine triphosphatase (ITPase) deficiency were shown to protect against ribavirin (RBV)-induced hemolytic anemia during early st ...
The main objective of the thesis is the study and the determination of an optimal navigation strategy, for a sailboat in an America's Cup race, by methods of stochastic optimization. Such methods are appropriate because the sailing team expects the wind to ...
It has long been suspected that host genetic factors influenced treatment outcome of hepatitis C virus (HCV) infection. Three independent genome-wide association studies have recently identified genetic variation in the IL28B gene (coding for IFN-λ3) that ...
Chronic infection with hepatitis C virus (HCV) affects 170 million people worldwide and is the leading cause of cirrhosis in North America. Although the recommended treatment for chronic infection involves a 48-week course of peginterferon-alpha-2b (PegIFN ...
Based on the results from a field survey campaign, this article describes three new developments which have been integrated to provide a comprehensive basis for the evaluation of overheating risk in offices. Firstly, a set of logistic regression equations ...
This paper presents a first approach to dynamic frequency-based transit assignment. As such the model aims to close the gap between schedule-based and frequency-based models. Frequency-based approaches have some advantages compared to schedule-based models ...
More than 500 million people worldwide are persistently infected with hepatitis B virus or hepatitis C virus. Although both viruses are poorly cytopathic, persistence of either virus carries a risk of chronic liver inflammation, potentially resulting in li ...
In this paper, two fixed per-information symbol complexity lossless source coding algorithms are modified for estimation and incremental LT decoding over piecewise stationary memoryless channels (PSMC's) with a bounded number of abrupt changes in channel s ...
Interferon (IFN) has been part of the standard treatment of chronic hepatitis B infection for more than 2 decades, yet the mechanism of action of this antiviral remains poorly understood. It was recently observed that members of the human APOBEC family of ...
More effective therapies are urgently needed against hepatitis C virus (HCV), a major cause of viral hepatitis. We used in vitro protein expression and microfluidic affinity analysis to study RNA binding by the HCV transmembrane protein NS4B, which plays a ...