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Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity

Publications associées (70)

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Gene expression profiling in cells with enhanced gamma-secretase activity

Alexandra Marie-Isabelle Karoline Brigitte Magold, Patrick Fraering

BACKGROUND: Processing by gamma-secretase of many type-I membrane protein substrates triggers signaling cascades by releasing intracellular domains (ICDs) that, following nuclear translocation, modulate the transcription of different genes regulating a div ...

Public Library of Science2009

Nano-Tera.CH: Nano-technologies for Tera-scale Problems

Giovanni De Micheli

The Nano-Tera.CH initiative is a broad engineering program in Switzerland for health and security of humans and the environment, currently funded by the Swiss government. The program rationale is rooted in advances in engineering nano-scale materials and t ...

IEEE2009

Target of rapamycin modulators of and use thereof

Yann Barrandon, Fahd Azzabi Zouraq

The present invention is related to new molecules capable of interacting with target of rapamycin (TOR) transcriptional complex. In particular, the present invention provides novel nucleic acid molecules, processes for production thereof, kits containing t ...

2009

Understanding engraftment of cultured epidermal stem cells

Nicolas Grasset

The epidermis and its appendages protect our body from environmental hazards. Cells generated in the basal layer continuously replace the terminally differentiated keratinocytes that are shed off the epidermal surface. Long-term renewal depends on specific ...

EPFL2008

Thymic epithelial cells

Paola Bonfanti

As primary lymphoid organ, the thymus provides the essential environment for maturation and selection of functional T lymphocytes. Thymic epithelial (TE) cells derive from the endoderm, and more specifically, from the third pharyngeal pouch. The thymic epi ...

EPFL2008

Control of adult stem cell function by bioengineered artificial niches

Matthias Lütolf

Stem cells are characterized by their dual ability to self- renew and differentiate, yielding essentially unlimited numbers of progeny that can replenish tissues with either high turnover such as blood and skin or contribute to the regeneration of organs w ...

Imperial College Press2008

Epithelial stem cells and mechanical signal transduction

Vincent Bernard Cattin

Hair follicles are cutaneous structures characteristic of mammals. These sensitive organs cycle and contain multipotent epithelial stem cells which are implicated in hair growth and hair cycle. A single whisker follicle of the rat hosts up to 1500 stem cel ...

EPFL2008

Epigenetic regulation of Hox gene activation: the waltz of methyls

Denis Duboule

Genetic studies have revealed that the antagonistic interplay between PcG and TrxG/MLL complexes is essential for the proper maintenance of vertebrate Hox gene expression in time and space. Hox genes must be silenced in totipotent embryonic stem cells and, ...

2008

Heterogeneity in multistage carcinogenesis and mixture modeling

Stephan Morgenthaler, Sandro Gsteiger

Carcinogenesis is commonly described as a multistage process, in which stem cells are transformed into cancer cells via a series of mutations. In this article, we consider extensions of the multistage carcinogenesis model by mixture modeling. This approach ...

BioMed Central2008

Block copolymers for siRNA delivery

Dominique André Rothenfluh, Marc Keller

The discovery of the RNA interference (RNAi) pathway in plants in the early 90's and the subsequent demonstration of its presence in mammalian cells in 2001 were a major breakthrough in biological research. Indeed it was quickly realized that this highly s ...

2008