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Engineering a stable future for DNA-origami as a biomaterial

Publications associées (33)

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The work presented focuses on the analysis of a police investigation implemented in the computing environment SCY-Lab. The prime objective is to check if the implementation of the situation helps pupils change their conceptions concerning the DNA molecule ...

2013

Detecting the translocation of DNA through a nanopore using graphene nanoribbons

Aleksandra Radenovic, Andras Kis, Ke Liu, Daria Krasnozhon, Camille Alice Raillon, Floriano Traversi, Mohamed Malik Benameur, Sergey Khlybov

Solid-state nanopores can act as single-molecule sensors and could potentially be used to rapidly sequence DNA molecules. However, nanopores are typically fabricated in insulating membranes that are as thick as 15 bases, which makes it difficult for the de ...

Nature Publishing Group2013

Lipid-coated nanocapillaries for DNA sensing

Vivek Vijay Thacker, Lorenz Jan Steinbock

We report a simple and efficient way to accomplish the chemical modification of glass nanopores by means of lipid self-assembly. Lipid coating improves the success rate of these glass nanopores as biosensors to detect lambda-DNA. ...

Royal Soc Chemistry2013

Study of Topoisomerase-DNA Interaction Using Atomic Force Microscopy

Livan Bladimir Alonso Sarduy

The aim of this thesis was to explore the topoisomerase-DNA interactions using atomic force microscopy (AFM) in a liquid environment. Firstly, we present a programmable microcontroller-driven injection system for the exchange of an imaging medium while usi ...

EPFL2012

Automated DNA purification from soil samples using Maxwell® 16

Pierre Rossi

The isolation of high quality DNA from environmental samples such as soil is essential for use in downstream applications. Two common issues often encountered with the purification of DNA from soil are the ability to fully lyse microbial organisms in the s ...

2012

DNA Topology

Guillaume Witz

This thesis explores different aspects of DNA topology through experimental and numerical techniques. Topology is a vast mathematical field, that deals with the spatial properties of objects undergoing continuous deformations, but here it is restricted to ...

EPFL2010

Transient Gene Expression in HEK-293E Cells for Recombinant Protein Production

Sophie Nallet

The growing demand of biopharmaceutical products is boosting the market for therapeutic recombinant proteins (r-proteins). More than half of the 140 r-proteins that have gained approval for human therapeutic use are manufactured in mammalian cells that mak ...

EPFL2010

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This paper examines reliable advancements in low-cost DNA- and immuno-chips. Capacitance detection was successfully chosen to develop label-free bio-chips. Probe immobilization was rigorously investigated in order to obtain reliable capacitance measurement ...

Elsevier2009

Interdigitated electrode DNA biosensor for detection of food-borne pathogens by impedance spectroscopy

Daniel Berdat

The commercial application of biosensors has had a significant impact in a number of areas, particularly in the field of medical diagnostics. But in spite of the great number of publications, only a few systems are commercially available in food analysis. ...

EPFL2009

Controlling DNA capture and propagation through artificial nanopores

Aleksandra Radenovic

Electrophorescing blopolymers across nanopores modulates the ionic current through the pore, revealing the polymer's diameter, length, and conformation. The rapidity of polymer translocation (similar to 30 000 bp/ms) in this geometry greatly limits the inf ...

American Chemical Society2007