Publication
Discovery and validation of temporal patterns involved in human brain ketometabolism in cerebral microdialysis fluids of traumatic brain injury patients
Publications associées (34)
Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines
Low intensity transcranial electrical stimulation (TES) in humans, encompassing transcranial direct current (tDCS), transcutaneous spinal Direct Current Stimulation (tsDCS), transcranial alternating current (tACS), and transcranial random noise (tRNS) stim ...
2017EEG paradigms as a supplemental tool to behavioral assessments of DOC
José del Rocio Millán Ruiz, Andrea Serino, Serafeim Perdikis, Jean-Paul Noel
Introduction Diagnosis and prediction of recovery in the acute phase of disorders of consciousness (DOC) are critical for subsequent medical decisions. However, reliable assessment remains elusive due to the inability of current validated clinical scales t ...
2017Improvement of Neuroenergetics by Hypertonic Lactate Therapy in Patients with Traumatic Brain Injury Is Dependent on Baseline Cerebral Lactate/Pyruvate Ratio
Pierre Magistretti, Reto Meuli, Luc Pellerin
Energy dysfunction is associated with worse prognosis after traumatic brain injury (TBI). Recent data suggest that hypertonic sodium lactate infusion (HL) improves energy metabolism after TBI. Here, we specifically examined whether the efficacy of HL (3h i ...
Mary Ann Liebert2016Sympathetic activity and early mobilization in patients in intensive and intermediate care with severe brain injuries: a preliminary prospective randomized study
Dimitri Nestor Alice Van De Ville
Background: Patients who experience severe brain injuries are at risk of secondary brain damage, because of delayed vasospasm and edema. Traditionally, many of these patients are kept on prolonged bed rest in order to maintain adequate cerebral blood flow, ...
BioMed Central2016Diagnostic approaches to predict persistent post-traumatic symptoms after mild traumatic brain injury - a literature review
Jean-Philippe Thiran, Alessandro Daducci
Mild traumatic brain injury (mTBI) is one of the most frequently diagnosed neurological disorders in emergency departments. Although there are established recommendations for the diagnosis and treatment in the acute stage, there is an on-going debate in wh ...
Taylor & Francis Ltd2016Outcome Prediction of Consciousness Disorders in the Acute Stage Based on a Complementary Motor Behavioural Tool
Dimitri Nestor Alice Van De Ville, Maria Giulia Preti, Bogdan Draganski, Richard Frackowiak, Djalel Eddine Meskaldji
Introduction Attaining an accurate diagnosis in the acute phase for severely brain-damaged patients presenting Disorders of Consciousness (DOC) is crucial for prognostic validity; such a diagnosis determines further medical management, in terms of therapeu ...
Public Library of Science2016Neuroenergetic Response to Prolonged Cerebral Glucose Depletion after Severe Brain Injury and the Role of Lactate
Pierre Magistretti, Jocelyne Bloch, Luc Pellerin
Lactate may represent a supplemental fuel for the brain. We examined cerebral lactate metabolism during prolonged brain glucose depletion (GD) in acute brain injury (ABI) patients monitored with cerebral microdialysis (CMD). Sixty episodes of GD (defined a ...
Mary Ann Liebert2015Proteomics of Cerebrospinal Fluid: Throughput and Robustness Using a Scalable Automated Analysis Pipeline for Biomarker Discovery
Cerebrospinal fluid (CSF) is a body fluid of high clinical relevance and an important source of potential biomarkers for brain-associated damages, such as traumatic brain injury and stroke, and for brain diseases, such as Alzheimer's and Parkinson's. Herei ...
Amer Chemical Soc2015Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI)
BACKGROUND: Current classification of traumatic brain injury (TBI) is suboptimal, and management is based on weak evidence, with little attempt to personalize treatment. A need exists for new precision medicine and stratified management approaches that inc ...
Lippincott, Williams & Wilkins2015Computational Modeling of Resting State Activity demonstrates Markers of Normalcy in Children with Pre- or Perinatal Stroke
Alessandra Griffa, Patric Hagmann
Children who sustain a prenatal or perinatal brain injury in the form of a stroke develop remarkably normal cognitive functions in certain areas, with a particular strength in language skills. A dominant explanation for this is that brain regions from the ...
Soc Neuroscience2015