Understanding ultrasound neuromodulation using a computationally efficient and interpretable model of intramembrane cavitation
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Single-neuron models are useful not only for studying the emergent properties of neural circuits in large-scale simulations, but also for extracting and summarizing in a principled way the information contained in electrophysiological recordings. Here we d ...
Identifying the structure and dynamics of synaptic interactions between neurons is the first step to understanding neural network dynamics. The presence of synaptic connections is traditionally inferred through the use of targeted stimulation and paired re ...
Two-photon calcium imaging enables functional analysis of neuronal circuits by inferring action potential (AP) occurrence ("spike trains") from cellular fluorescence signals. It remains unclear how experimental parameters such as signal-to-noise ratio (SNR ...
To appreciate how neural circuits in the brain control behaviors, we must identify how the neurons comprising the circuit are connected. Neuronal connectivity is difficult to determine experimentally, whereas neuronal activity can often be readily measured ...
Cortical neurons continuously transform sets of incoming spike trains into output spike trains. This input-output transformation is referred to as single-neuron computation and constitutes one of the most fundamental process in the brain. A deep understand ...
An important feature of the nervous system is its ability to adapt to new stimuli. This adaptation allows for optimal encoding of the incoming information by dynamically changing the coding strategy based upon the incoming inputs to the neuron. At the leve ...
Neural circuits closer to the periphery tend to be organised in a topological way, i.e. stimuli which are spatially close tend to be mapped onto neighbouring processing neurons. The goal of this study is to show how motion features (optic-flow), which have ...
Most neurons in peripheral sensory pathways initially respond vigorously when a preferred stimulus is presented, but adapt as stimulation continues. It is unclear how this phenomenon affects stimulus coding in the later stages of sensory processing. Here, ...
Neural firing is often subject to negative feedback by adaptation currents. These currents can induce strong correlations among the time intervals between spikes. Here we study analytically the interval correlations of a broad class of noisy neural oscilla ...
To understand how the central nervous system performs computations using recurrent neuronal circuitry, simulations have become an indispensable tool for theoretical neuroscience. To study neuronal circuits and their ability to self-organize, increasing att ...