Early sepsis diagnosis via protein and miRNA biomarkers using a novel point-of-care photonic biosensor
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The sheer size of the protein sequence space is massive: a protein of 100 residues can have 20^100 possible sequence combinations; and knowing that this exceeds the number of atoms in the universe, the chance of randomly discovering a stable new sequence w ...
EPFL2022
Urinary tract infections (UTIs) are amongst the most common bacterial infections and are the second-most frequent reason for antibiotic prescriptions. Moreover, in about 25% of all treated cases, recurrence of infection occurs. Uropathogenic Escherichia co ...
EPFL2021
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Background: Resistance to enteric pathogens is a complex trait at the crossroads of multiple biological processes. We have previously shown in the Drosophila Genetic Reference Panel (DGRP) that resistance to infection is highly heritable, but our understan ...
2020
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The implementation of multiplexed point-of-care biosensors is a top priority to address the current epidemic problems originated by widespread pathogenic infections, like those caused by viruses or bacteria. A rapid and accurate detection, identification, ...
SPIE-INT SOC OPTICAL ENGINEERING2018
Healthcare-associated infections (HAIs) are an important health issue around the world. The consequences of HAIs incidence include prolonged hospital stays, increased resistance of microorganisms to antimicrobials, higher costs for health systems and for t ...
EPFL2017
This thesis addresses the preparation of antibacterial surfaces for hospital facilities taking biomedical thin polymer films, textiles and catheter as probes. Magnetron sputtering is used to apply the coatings leading to fast bacterial inactivation in the ...
EPFL2016
Recent progress in protein engineering, empowered by the rapidly evolving fields of synthetic biology and DNA synthesis, has enabled the generation of various custom-designed proteins. Their thorough analysis has led to applications in areas including medi ...
Source localization, the act of finding the originator of a disease or rumor in a network, has become an important problem in sociology and epidemiology. The localization is done using the infection state and time of infection of a few designated sensor no ...
Objectives: The management of bloodstream infection, a life-threatening disease, largely relies on early detection of infecting microorganisms and accurate determination of their antibiotic susceptibility to reduce both mortality and morbidity. Recently we ...
One out of three pediatric sepsis deaths in high income countries occur in previously healthy children. Primary immunodeficiencies (PIDs) have been postulated to underlie fulminant sepsis, but this concept remains to be confirmed in clinical practice. Pseu ...
