Publication
A Tale of Two Tumors: Unraveling the Complexities of Epigenetic Dysregulation in Cancer
Publications associées (157)
PD-1-cis IL-2R agonism yields better effectors from stem-like CD8(+) T cells
Douglas Hanahan, Mélanie Louise Tichet, Petra Catalina Schwalie, Stephan Wullschleger, Maria Karagianni
Expansion and differentiation of antigen-experienced PD-1(+)TCF-1(+) stem-like CD8(+) T cells into effector cells is critical for the success of immunotherapies based on PD-1 blockade(1-4). Hashimoto et al. have shown that, in chronic infections, administr ...
NATURE PORTFOLIO2022PR-DUB preserves Polycomb repression by preventing excessive accumulation of H2Aub1, an antagonist of chromatin compaction
The Polycomb repressive complexes PRC1, PRC2, and PR-DUB repress target genes by modifying their chromatin. In Drosophila, PRC1 compacts chromatin and monoubiquitinates histone H2A at lysine 118 (H2Aub1), whereas PR-DUB is a major H2Aub1 deubiquitinase, bu ...
2022Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections
Didier Trono, Julien Paul André Pontis, Yu Tao
The transcription factor network required for primordial germ cell (PGC) specification is known to diverge in mammals. Here the authors show that hominidae-specific transposable element (TE) LTR5Hs becomes transcriptionally active during PGC specification, ...
NATURE PORTFOLIO2022High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites
Binding of mammalian transcription factors (TFs) to regulatory regions is hindered by chromatin compaction and DNA methylation of their binding sites. Nevertheless, pioneer transcription factors (PFs), a distinct class of TFs, have the ability to access nu ...
NATURE RESEARCH2021Toward a mechanistic understanding of variable chromatin modules
Our genome is a long sequence of DNA that contains all the information to be able to constitute a living organism like us, similarly to what the letters in a book do to create a story. This sequence, which is a stretch of molecules called nucleotides, is a ...
EPFL2021An autonomous microfluidic device for identification and analysis of individual clinically-relevant mammalian cells
Fabien Louis Claude Robert Jammes
Cancer represents one of the major public health challenges worldwide, representing more than 25% of all deaths in the European Union in 2014. It affects a large and growing part of the general population, with the National Cancer Institute (NCI) estimatin ...
EPFL2021Induction of a chromatin boundary in vivo upon insertion of a tad border
Denis Duboule, Lucille Delisle, Christopher Chase Bolt, Edgardo Rodriguez Carballo, Marie-Laure Gadolini
Author summary During development, enhancer sequences tightly regulate the spatio-temporal expression of target genes often located hundreds of kilobases away. This complex process is made possible by the folding of chromatin into domains, which are separa ...
PUBLIC LIBRARY SCIENCE2021Notch1-driven T-ALL chromatin landscape is regulated by Tcf1 in hematopoietic progenitors
Notch1 receptor signaling is essential for T cell fate specification and physiological thymic T lymphocyte development. Its dysregulation and oncogenic activation are detected in almost 80% of pediatric patients suffering from T cell acute lymphoblastic le ...
EPFL2021Histone acetylation dynamics modulates chromatin conformation and allele-specific interactions at oncogenic loci
Elisa Oricchio, Daniele Tavernari, Natalya Katanayeva, Stephanie Jocelyne Sungalee, Ruxandra-Andreea Lambuta, Giovanni Ciriello
In cancer cells, enhancer hijacking mediated by chromosomal alterations and/or increased deposition of acetylated histone H3 lysine 27 (H3K27ac) can support oncogene expression. However, how the chromatin conformation of enhancer-promoter interactions is a ...
2021KRAB zinc finger protein-mediated control of transposon-embedded regulatory sequences from human germline to early embryos
Transposable elements (TEs), also called jumping genes, are genetic elements capable of changing their position within the genome of their host. They make up large fractions of genomes, including 45% of human DNA content, according to current estimates.
S ...
EPFL2021