Microscale physico-chemical interactions between hydrodynamically confined liquids and immersed biological surfaces
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Low-cost and high-resolution on-chip microscopes are vital for reducing cost and improving efficiency for modern biomedicine and bioscience. Despite the needs, the conventional microscope design has proven difficult to miniaturize. Here, we report the impl ...
versatile strategy to rapidly immobilize complex gradients of virtually any desired protein on soft poly(ethylene glycol) (PEG) hydrogel surfaces that are reminiscent of natural extracellular matrices (ECM) is reported. A microfluidic chip is used to gener ...
We form water-in-oil droplets in a microfluidic channel-nozzle geometry for studying the influence of viscosity of oil and of different oil classes on the droplet size. We find that the chemical structure of oil dominates over its viscosity. Our studies ar ...
Elsevier Science, Reg Sales Off, Customer Support Dept, 655 Ave Of The Americas, New York, Ny 10010 Usa2009
We present leakage-free valves and an efficient fixed-volume mixer fabricated using a four-layer soft lithography technique in polydimethylsiloxane (PDMS). Mixing is achieved with a 95% efficiency in a few seconds by creating circular flow patterns inside ...
Elsevier Science, Reg Sales Off, Customer Support Dept, 655 Ave Of The Americas, New York, Ny 10010 Usa2009
A microchip reactor has been developed on the basis of a layer-by-layer approach for fast and sensitive digestion of proteins. The resulting peptide analysis has been carried out by matrix-assisted laser desorption ionization timeof- flight mass spectromet ...
We present an original concept of manipulation of magnetic microbeads in a microchannel. It is based on the dynamic motion of a self-assembled structure of ferrimagnetic beads that are retained within a microfluidic flow using a local alternating magnetic ...
In analytical separation technology there is a great demand for faster and more effective separation process. Miniaturization is a suitable technique for satisfying this demand because the reduction of the separation systems in size would give increased se ...
Many fundamental processes that govern the function of biological cells occur on or immediately under the cell membrane. Fluorescence marking of specific sites has had a large impact in the recognition of these processes. In addition, observation in an app ...
The demand for tools suitable for deposition of small amount of material is continuously increasing. A standard SiN cantilever was modified in order to dispense single droplets of femto- and ato-liter (NAnoscale DISpensing (NADIS)). In order to open a nano ...