Publication
Common genetic variants associated with Parkinson's disease display widespread signature of epigenetic plasticity
Publications associées (32)
Visual masking deficits in schizophrenia: A view into the genetics of the disease through an endophenotype
Michael Herzog, Jacques Fellay, Maya Roinishvili, Flavia Aurelia Shoko Hodel
Schizophrenia is a chronic disorder determined by a complex mix of genetic and environmental factors. To better understand the contributions of human genetic variation to schizophrenia, we performed a genome-wide association study of a validated endophenot ...
2018The phenotypic impact of naturally occurring genetic and molecular mitochondrial variation in a Drosophila Genetic Reference Population
Genome-wide association (GWA) studies aim to dissect the relationship between genotype and phenotype. So far, the focus has been on nuclear genetic determinants as variation in the mitochondrial genome is often low in the study cohorts. Despite this observ ...
EPFL2018Genetic determinants of healthy human immune variance: from humoral response to microbiome diversity
Identifying the drivers of the observed interindividual variability of the human immune system is crucial to our understanding of infectious and immune-mediated diseases. The contribution of genetic and non-genetic factors to immunological differences betw ...
EPFL2018Methods of diagnosis alzheimer's disease
Johannes Gräff, Jose Vicente Sanchez Mut
A method for the diagnosis or prognosis of Alzheimer's disease (AD), includes the steps of placing a sample isolated from a person suspected of having AD onto a substrate labeling the sample to identify at least one epigenetic marker and/or genetic variati ...
2018The Genetics of Transcription Factor DNA Binding Variation
Bart Deplancke, Vincent Roland Julien Gardeux, Daniel Alpern
Most complex trait-associated variants are located in non-coding regulatory regions of the genome, where they have been shown to disrupt transcription factor (TF)-DNA binding motifs. Variable TF-DNA interactions are therefore increasingly considered as key ...
Elsevier2016TEMPLE: analysing population genetic variation at transcription factor binding sites
Stefan Jean Laurent, Maria Litovchenko
Genetic variation occurring at the level of regulatory sequences can affect phenotypes and fitness in natural populations. This variation can be analysed in a population genetic framework to study how genetic drift and selection affect the evolution of the ...
Wiley-Blackwell2016Human genetic variation in HIV disease: beyond genome-wide association studies
PURPOSE OF REVIEW: Rapid expansion of genomic technologies has resulted in an unprecedented ability to interrogate the impact of human genetic variation on disease. HIV-1 infection is a unique model for studying this impact because host genetic variation i ...
Lippincott Williams & Wilkins2015The impact of host genetic variation on infection with HIV-1
The outcome after infection with the human immunodeficiency virus type 1 (HIV-1) is a complex phenotype determined by interactions among the pathogen, the human host and the surrounding environment. An impact of host genetic variation on HIV-1 susceptibili ...
Nature Publishing Group2015Biodiversity dynamics and the effect of urban environment on the distribution of genetic variation in the Geneva cross-border area
Stéphane Joost, Idris Guessous, Jens Ingensand, Estelle Rochat, Kevin Leempoel, Ivo Widmer, Alain Clémence
Population growth, urbanization and agriculture lead to degradation and loss of natural environment. This has an adverse effect on the diversity of habitats, species and genes and might cause decline in the quality of life of the resident population. In th ...
2015Population Variation and Genetic Control of Modular Chromatin Architecture in Humans
Bart Deplancke, David Hacker, Sebastian Martin Waszak, Sunil Kumar Raghav, Nouria Hernandez, Gilles Udin, Alisa Yurovsky, Sarah Thurnheer
Chromatin state variation at gene regulatory elements is abundant across individuals, yet we understand little about the genetic basis of this variability. Here, we profiled several histone modifications, the transcription factor (TF) PU.1, RNA polymerase ...
Elsevier2015