In vivo evaluation of gene editing and prosthetic strategies to restore vision in small and large animal models of retinal degeneration
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Background: In age related macular degeneration and inherited dystrophies, preservation of retinal ganglion cells has been demonstrated. This finding has led to the development of various models of subretinal or epiretinal implant in order to restore visio ...
We describe a set of simulations to evolve omnidirectional active vision, an artificial retina scanning over images taken via an omnidirectional camera, being applied to a car driving task. While the retina can immediately access features in any direction, ...
We analyze whether Independant Component Analysis (ICA) is an appropriate tool for estimating spatial information in spatiochromatic mosaiced color images. In previous studies, ICA analysis of natural color scenes (Hoyer et al. 2000; Tailor et al., 2000; W ...
In this paper, we analyze whether Principal Component Analysis (PCA) is an appropriate tool for estimating spatial information in spatio- chromatic mosaiced images. Ruderman et al. 1 have shown that the spatio- chromatic principal components of cone images ...
BACKGROUND: Conventional photocoagulation of subfoveal choroidal neovascularization (CNV) is often accompanied by visual loss due to thermal damage to adjacent retinal structures. Photodynamic therapy (PDT) allows vascular occlusion by selective photochemi ...
To study the relationship among tyrosinase activity, melanin production, and the routing of retinal ganglion cell (RGC) axons at the optic chiasm, we analysed mice with varying doses of the tyrosinase gene. These include the dark-eyed albino (Tyrc44H), a r ...
Conditional gene targeting using the Cre/loxP system enables specific deletion of a gene in a tissue of interest. For application of Cre-mediated recombination in pigment cells, Cre expression has to be targeted to pigment cells in transgenic mice. So far, ...
Assuming that the photoreceptor response of the human visual system is adaptive and non-linear, we can derive mathematical properties that can account for both color discrimination and chromatic adaptation. This could be due to the photoreceptors’ response ...
For most retinal degeneration disorders, no efficient treatment exists to preserve photoreceptors (PRs) and, consequently, to maintain vision. Gene transfer appears to be a promising approach to prevent PR loss. In order to design adequate vectors to targe ...
OBJECTIVE: To evaluate the safety and short-term visual and fluorescein angiographic effects of a single photodynamic therapy treatment with verteporfin with the use of different dosage regimens in patients with choroidal neovascularization (CNV) from age- ...
