Publication
The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche
Publications associées (69)
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The study of hormone action in the human breast has been hampered by lack of adequate model systems. Upon in vitro culture, primary mammary epithelial cells tend to lose hormone receptor expression. Widely used hormone receptor positive breast cancer cell ...
Journal of Visualized Experiments2015Endocrine hormones and local signals during the development of the mouse mammary gland
Most of mammary gland development occurs postnatally under the control of female reproductive hormones, which in turn interact with other endocrine factors. While hormones impinge on many tissues and trigger very complex biological responses, tissue recomb ...
Wiley-Blackwell2015Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch
Freddy Radtke, Luca Pellegrinet
Genetic data indicate that abrogation of Notch-Rbpj or Wnt-beta-catenin pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due to the aberrant differentiation of the transit-amplifying cells ...
Company of Biologists20153D niche microarrays for systems-level analyses of cell fate
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The behaviour of mammalian cells in a tissue is governed by the three-dimensional (3D) microenvironment and involves a dynamic interplay between biochemical and mechanical signals provided by the extracellular matrix (ECM), cell–cell interactions and solub ...
Nature Publishing Group2014The role of recruited bone-marrow derived mesenchymal stem cells in the establishment of the tumor stroma and a growth-supportive environment
The Mesenchymal Stem Cell (MSC) is a self-renewing multipotent progenitor originally found in the bone marrow. It has drawn strong interest from translational research because of the multipotency of MSCs, their immunosuppression, their intrinsic homing and ...
EPFL2014Temperature impacts human epidermal stem cell behaviour through thermoTRPs and mTOR signalling
Adult stem cells are characterized by their unique ability to self-renew and give rise to a progeny of specialized/differentiated cells. Therefore, they have a remarkable potential for regenerative medicine. However, the use of adult stem cells is restrain ...
EPFL2013Interactions between cancer stem cells and their niche govern metastatic colonization
Albert Santamaria Martinez, Ilaria Malanchi, Hans-Anton Lehr
Metastatic growth in distant organs is the major cause of cancer mortality. The development of metastasis is a multistage process with several rate-limiting steps. Although dissemination of tumour cells seems to be an early and frequent event, the successf ...
2012ER and PR signaling nodes during mammary gland development
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The ovarian hormones estrogen and progesterone orchestrate postnatal mammary gland development and are implicated in breast cancer. Most of our understanding of the molecular mechanisms of estrogen receptor (ER) and progesterone receptor (PR) signaling ste ...
BioMed Central2012Lrig1: a new master regulator of epithelial stem cells
The intestine represents the most vigorously renewing, adult epithelial tissue that makes maintenance of its homeostasis a delicate balance between proliferation, cell cycle arrest, migration, differentiation, and cell death. These processes are precisely ...
2012Autocrine and paracrine unpaired signalling regulate intestinal stem cell maintenance and division
Bruno Lemaitre, Sveta Chakrabarti, Dani Osman, Yu-Ting Huang, Yu-Chen Tsai
The Janus Kinase (JAK) Signal Transducer and Activator of Transcription (STAT) pathway is involved in the regulation of Intestinal Stem Cell (ISC) activity to ensure a continuous renewal of the adult Drosophila midgut. Three ligands, Unpaired1, 2 and 3 are ...
Company Of Biologists Ltd2012