Publication
Somatostatin enhances visual processing and perception by suppressing excitatory inputs to parvalbumin-positive interneurons in V1
Publications associées (73)
Principles of Network Plasticity in Neocortical Microcircuits
Synaptic plasticity underlies our ability to learn and adapt to the constantly changing environment. The phenomenon of synapses changing their efficacy in an activity-dependent manner is often studied in small groups of neurons in vitro or indirectly throu ...
EPFL2023Membrane potential dynamics of excitatory and inhibitory neurons in mouse barrel cortex during active whisker sensing
Carl Petersen, Sylvain Crochet, Aurélie Pala, Taro Kiritani, Célia Roxane Gasselin
Neocortical neurons can increasingly be divided into well-defined classes, but their activity patterns during quantified behavior remain to be fully determined. Here, we obtained membrane potential recordings from various classes of excitatory and inhibito ...
PUBLIC LIBRARY SCIENCE2023Pathway and directional specificity of Hebbian plasticity in the cortical visual motion processing network
Friedhelm Christoph Hummel, Estelle Emeline Raffin, Michele Bevilacqua
Cortico-cortical paired associative stimulation (ccPAS), which repeatedly pairs single-pulse transcranial magnetic stimulation (TMS) over two distant brain regions, is thought to modulate synaptic plasticity. We explored its spatial selectivity (pathway an ...
2023A subpopulation of cortical VIP-expressing interneurons with highly dynamic spines
Graham Knott, Jérôme Blanc, Christina Georgiou, Kok Sin Lee
Structural synaptic plasticity may underlie experience and learning-dependent changes in cortical circuits. In contrast to excitatory pyramidal neurons, insight into the structural plasticity of inhibitory neurons remains limited. Interneurons are divided ...
NATURE PORTFOLIO2022Learning-related congruent and incongruent changes of excitation and inhibition in distinct cortical areas
Carl Petersen, Sylvain Crochet, Romain Guiet, Vahid Esmaeili, Yanqi Liu, Georgios Foustoukos, Keita Tamura, Anastasiia Oryshchuk, Reza Asri
Excitatory and inhibitory neurons in diverse cortical regions are likely to contribute differentially to the transformation of sensory information into goal-directed motor plans. Here, we investigate the relative changes across mouse sensorimotor cortex in ...
2022Disruption of layer-specific visual processing in a model of focal neocortical epilepsy
Silvestro Micera, Matteo Vissani
The epileptic brain is the result of a sequence of events transforming normal neuronal populations into hyperexcitable networks supporting recurrent seizure generation. These modifications are known to induce fundamental alterations of circuit function and ...
OXFORD UNIV PRESS INC2022High synaptic threshold for dendritic NMDA spike generation in human layer 2/3 pyramidal neurons
James Gonzalo King, Suraj Honnuraiah
Neurons receive synaptic input primarily onto their dendrites. While we know much about the electrical properties of dendrites in rodents, we have only just started to describe their properties in the human brain. Here, we investigate the capacity of human ...
2022Three-dimensional multilayer concentric bipolar electrodes restrict spatial activation in optic nerve stimulation
Diego Ghezzi, Eleonora Borda, Ricardo Camilo Moreira, Marta Jole Ildelfonsa Airaghi Leccardi, Vivien Gaillet, Elodie Geneviève Zollinger
Objective. Intraneural nerve interfaces often operate in a monopolar configuration with a common and distant ground electrode. This configuration leads to a wide spreading of the electric field. Therefore, this approach is suboptimal for intraneural nerve ...
IOP Publishing Ltd2022Long term effects of peripubertal stress on excitatory and inhibitory circuits in the prefrontal cortex of male and female mice
The impact of stressful events is especially important during early life, because certain cortical regions, especially the prefrontal cortex (PFC), are still developing. Consequently, aversive experiences that occur during the peripubertal period can cause ...
ELSEVIER SCIENCE INC2021Enhancing visual motion discrimination by desynchronizing bifocal oscillatory activity
Friedhelm Christoph Hummel, Estelle Emeline Raffin, Roberto Felipe Salamanca Giron, Sarah Bernardina Zandvliet, Martin Seeber
Visual motion discrimination involves reciprocal interactions in the alpha band between the primary visual cortex (V1) and mediotemporal areas (V5/MT). We investigated whether modulating alpha phase synchronization using individualized multisite transcrani ...
2021