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Intracellular recording of cardiomyocyte action potentials with nanopatterned volcano-shaped microelectrodes

Publications associées (71)

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Neuronal membrane potential is of fundamental importance for the mechanistic understanding of brain function. This review discusses progress in whole-cell patch-clamp recordings for low-noise measurement of neuronal membrane potential in awake behaving ani ...

Cell Press2017

Isogeometric approximation of cardiac electrophysiology models on surfaces: An accuracy study with application to the human left atrium

Alfio Quarteroni, Toni Mikael Lassila, Andrea Bartezzaghi, Alessandro Samuele Patelli

We consider Isogeometric Analysis in the framework of the Galerkin method for the spatial approximation of cardiac electrophysiology models defined on NURBS surfaces; specifically, we perform a numerical comparison between basis functions of degree p >= 1 ...

Elsevier2017

Light-evoked hyperpolarization and silencing of neurons by conjugated polymers

Diego Ghezzi, Mattia Nova

The ability to control and modulate the action potential firing in neurons represents a powerful tool for neuroscience research and clinical applications. While neuronal excitation has been achieved with many tools, including electrical and optical stimula ...

2016

Effect of Ionic Diffusion on Extracellular Potentials in Neural Tissue

Daniel Keller

Recorded potentials in the extracellular space (ECS) of the brain is a standard measure of population activity in neural tissue. Computational models that simulate the relationship between the ECS potential and its underlying neurophysiological processes a ...

Public Library of Science2016

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We present the development of a mechanically active bioreactor. Using dielectric elastomer actuators (DEA), we are able to mechanically perturb cell cultures in a controlled environment. With tailored pre-strain and compliant electrodes, it is possible to ...

2016

Biomimetic surface patterning for long-term transmembrane access

Philippe Renaud, Jules John Vandersarl

Here we present a planar patch clamp chip based on biomimetic cell membrane fusion. This architecture uses nanometer length-scale surface patterning to replicate the structure and function of membrane proteins, creating a gigaohm seal between the cell and ...

Nature Publishing Group2016

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Despite decades of extracellular action potential (EAP) recordings monitoring brain activity, the biophysical origin and inherent variability of these signals remains enigmatic. We performed whole-cell patch recordings of excitatory and inhibitory neurons ...

American Physiological Society2015

Organic bioelectronics aims at the intimate integration between organic materials and biological tissues in order to obtain a targeted functional outcome. In the last decades, conductive polymers have been successfully employed to interface excitable cells ...

2015

The thalamus transmits sensory information to the neocortex and receives neocortical, subcortical, and neuromodulatory inputs. Despite its obvious importance, surprisingly little is known about thalamic function in awake animals. Here, using intracellular ...

Elsevier2015

Intracellular recordings of membrane potential in vitro have defined fundamental properties of synaptic communication. Much less is known about the properties of synaptic connectivity and synaptic transmission in vivo. Here, we combined single-cell opto-ge ...

Cell Press2015