A system for providing neuromodulation, especially neurostimulation
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Throwing is a complex and highly dynamic task. Humans usually exploit passive dynamics of their limbs to optimize their movement and muscle activation. In order to approach human throwing, we developed a double pendulum robotic platform. To introduce passi ...
Photodynamic therapy (PDT) affects vascular barrier function and thus increases vessel permeability. This phenomenon may be exploited to facilitate targeted drug delivery and may lead to a new clinical application of photodynamic therapy. Here, we investig ...
Aims Statins protect against cardiovascular-related mortality but induce skeletal muscle toxicity. To investigate mechanisms of statins, we tested the hypothesis that statins optimized cardiac mitochondrial function but impaired vulnerable skeletal muscle ...
An approach to extend the field of view of a miniaturised imaging system is introduced. This innovative approach uses multiple optical systems working in parallel and image post-processing. As an example, a module consisting of a central single micro-lens ...
The coupling between cardiac mechanics and electric signaling is addressed in a nonstandard framework in which the electrical potential dictates the active strain (not stress) of the muscle. The physiological and mathematical motivations leading us to this ...
Society for Industrial and Applied Mathematics2011
Monaco V, Ghionzoli A, Micera S. Age-related modifications of muscle synergies and spinal cord activity during locomotion. J Neurophysiol 104: 2092-2102, 2010. First published August 4, 2010; doi:10.1152/jn.00525.2009. Recent findings have shown that neura ...
Robotic assistive devices have been developed and are now being introduced in clinical environments. Such robots can advantageously provide long raining, with quantifiable mobilization (force and position). But in the event of a complete lesion the patient ...
Knee joint impedance varies substantially during physiological gait. Quantifying this modulation is critical for the design of transfemoral prostheses that aim to mimic physiological limb behavior. Conventional methods for quantifying joint impedance typic ...
To better understand normative behavior for quantitative evaluation of motor recovery after injury, we studied arm movements by non-injured Rhesus monkeys during a food-retrieval task. While seated, monkeys reached, grasped, and retrieved food items. We re ...
The delivery of molecules and genes to the central nervous system (CNS) poses a major challenge for the treatment of neurodegenerative diseases. CNS disorders require long-term intervention and the presence of the blood-brain barrier (BBB) restricts the pe ...